What is a plasma renin activity LC MS MS test for?

Plasma Renin Activity, LC/MS/MS – Measurement of the Plasma Renin activity is useful in evaluating hypertension.

What causes high plasma renin activity LC MS MS?

A high level of renin may be due to: Adrenal glands that do not make enough hormones (Addison disease or other adrenal gland insufficiency) Bleeding (hemorrhage) Heart failure.

What is high plasma renin activity?

Plasma renin activity (PRA) is measured as part of the diagnosis and treatment of hypertension (high blood pressure). Patients with primary hyperaldosteronism will have increased aldosterone (for more information see the aldosterone test) production associated with a decreased PRA.

What is low plasma renin activity?

Low-renin hypertension has also been defined as plasma renin activity less than 1 ng/mL/hr in the recumbent position while on a normal sodium diet. 145. Low plasma renin activity is associated with salt-sensitive hypertension and has been used as a surrogate marker for salt sensitivity.

What causes low plasma renin activity?

Third, a low-renin/low aldosterone status may result from a marked reduction in nephron number and function. These conditions include diabetic nephropathy, chronic glomerulonephritis, congenital solitary kidney, unilateral nephrectomy or ageing.

What results if the kidney produces too much renin?

High renin levels could mean that you have: Addison’s disease (when your adrenal glands don’t make enough hormones) from volume depletion. Dehydration. Low potassium levels in your blood (hypokalemia).

What is the normal range for renin activity?

Normal Results Normal values range from 0.2 to 3.3 nanograms per milliliter per hour (ng/mL/hour) or 0.056 to 0.92 nanograms per liter per second (ng/L/s). Normal value ranges may vary slightly among different laboratories.

How do you treat high renin levels?

Renal hypertension (high renin/high aldosterone) is best treated with angiotensin receptor antagonists; primary aldosteronism (low renin/high aldosterone) is best treated with aldosterone antagonists (spironolactone or eplerenone); and hypertension due to overactivity of the renal epithelial sodium channel (low renin/ …

What are the symptoms of low renin levels?

Aside from high blood pressure, primary aldosteronism is usually associated with muscle weakness and low potassium levels in your blood (hypokalemia). This can cause increased thirst, cramps, and weakness.

How common is low renin hypertension?

LRH is a common condition, accounting for 20 to 30% of all hypertensive patients and includes the most frequent essential form and a number of secondary and genetic subtypes.

How is low renin treated?

In the case of primary aldosteronism, the treatment of choice is aldosterone antagonism (or adrenalectomy in the case of adrenal adenoma). For low-renin essential hypertension, a higher success rate has been reported with a first-line treatment based on diuretics and vasodilators.

How does renin affect the kidneys?

Renin, which is released primarily by the kidneys, stimulates the formation of angiotensin in blood and tissues, which in turn stimulates the release of aldosterone from the adrenal cortex. Renin is a proteolytic enzyme that is released into the circulation by the kidneys.