What is a MRC-5 cell?

MRC-5 is the most common human diploid cell line used in production of viral vaccines; mesenchymal stem cells (MSCs) is a type of adult multipotent stem cells. Both cell types share the same fibroblast-like morphology and maintain a normal diploid karyotype over long in vitro expansion.

What are imr90 cells?

The IMR-90 cell line is made up of fibroblasts isolated from the normal lung tissue. The cell line may be used as an alternate to WI-38 and other human lung cell strains, considering division potential and viral susceptibilities. Homo sapiens, human.

What are Hs68 cells?

Hs68 is one of a series of human foreskin fibroblast lines developed at the Naval Biosciences Laboratory (NBL) in Oakland, CA. The material was obtained from an apparently normal Caucasian newborn male in February, 1969. This is a human cell line with the normal 46,XY karyotype.

Where does WI-38 come from?

WI-38 is a diploid human cell line composed of fibroblasts derived from lung tissue of a 3-month-gestation female fetus. The fetus came from the elective abortion of a Swedish woman in 1962, and was used without her knowledge or permission.

What is cell line definition?

Cell line is a general term that applies to a defined population of cells that can be maintained in culture for an extended period of time, retaining stability of certain phenotypes and functions. Cell lines are usually clonal, meaning that the entire population originated from a single common ancestor cell.

What are hep2 cells?

The HEp-2 cell, a native protein array with hundreds of antigens, provides an ideal substrate for the detection of ANA1. The detection of ANA in human serum is an important screening tool for connective tissue diseases, and IIF is the reference method for ANA testing1.

What are H9 cells?

H9 and BG02 are human embryonic stem cell lines. The cells are adherent in culture. The H9 karyotype is XX euploid.

What are human diploid cells in vaccines?

To date, there are two human diploid cell lines which were originally prepared from tissues of aborted foetuses (in 1964 and 1970) and are used for the preparation of vaccines based on live attenuated virus: the first one is the WI-38 line (Winstar Institute 38), with human diploid lung fibroblasts, coming from a …

What are WISH cells?

The mechanism whereby second messengers induce PG release is not clear, and a crosstalk between the two transduction pathways could be hypothesized. This interaction has extensively been analysed in “WISH” cells, a human amnion-derived cell line, which represent a model for the in vitro study of amnion functions.