What is a cytopathic effect of a virus?
What is a cytopathic effect of a virus?
cytopathic effect (CPE), structural changes in a host cell resulting from viral infection. CPE occurs when the infecting virus causes lysis (dissolution) of the host cell or when the cell dies without lysis because of its inability to reproduce.
What are some examples of cytopathic effects of viruses?
Morphologic Effects: The changes in cell morphology caused by infecting virus are called cytopathic effects (CPE). Common examples are rounding of the infected cell, fusion with adjacent cells to form a syncytia (polykaryocytes), and the appearance of nuclear or cytoplasmic inclusion bodies.
What is CPE of rabies?
A CPE can be produced regularly in rabies virus-infected McCoy cells, after a lytic type of infection (Fig. l), permitting the titration of virus or antibodies against rabies by direct morphological observation on an infected culture.
What are the virulence factors of rabies?
The major factors that determine the virulence of RV are virus uptake, cell-to-cell spread, the rate of virus replication and the expression of the RV glycoprotein (G).
Which of the following are types of cytopathic effects?
Types of Cytopathic effects
| Cytopathic effect(s) | Virus(es) |
|---|---|
| Nuclear shrinking (pyknosis), proliferation of membrane | Picornaviruses |
| Proliferation of nuclear membrane | Alphaviruses, herpesviruses |
| Vacuoles in cytoplasm | Polyomaviruses, papillomaviruses |
| Syncytium formation (cell fusion) | Paramyxoviruses, coronaviruses |
What is the pathogenesis of rabies?
Pathogenesis. After inoculation, rabies virus may enter the peripheral nervous system directly and migrates to the brain or may replicate in muscle tissue, remaining sequestered at or near the entry site during incubation, prior to central nervous system invasion and replication.
What is the meaning of cytopathic?
Definition of cytopathic : of, relating to, characterized by, or producing pathological changes in cells.
Are there 2 types of rabies?
Scientists studying hundreds of genome sequences of the rabies virus at the Institut Pasteur have shown that two major viral types – bat rabies and dog rabies – evolved in different ways. These genetic data provide evolutionary models that may explain transmission between one species and another.
