What is a contraindication for cholinesterase inhibitor therapy?

What is a contraindication for cholinesterase inhibitor therapy?

Cautious administration of cholinesterase inhibitors is advised in patients who have a previous history of allergy or adverse reactions to prior cholinesterase inhibitors, severe liver disease, preexisting bradycardia, peptic ulcer disease, current alcoholism, asthma, or chronic obstructive pulmonary disease.

What are the side effects of acetylcholinesterase inhibitors?

The most common adverse effects of cholinesterase inhibitors include nausea, diarrhea, vomiting, decreased appetite, dyspepsia, anorexia, muscle cramps, fatigue, insomnia, dizziness, headache, and asthenia. Taking these medications with food, preferably a full meal, can mitigate these gastrointestinal effects.

What is the effect of an acetylcholinesterase inhibitor on heart rate?

It is likely that the major effect of acetylcholinesterase inhibition in patients with POTS is the reduction in heart rate through augmentation of parasympathetic tone.

Which drug has effect on acetylcholinesterase?

List of Cholinesterase inhibitors:

When do you stop acetylcholinesterase inhibitors?

Although some patients with moderately severe disease experience clinical benefits from cholinesterase inhibitor therapy, it is reasonable to consider discontinuing therapy when a patient has progressed to advanced dementia with loss of functional independence, thus making the use of the therapy—ie, to preserve …

What is the aim when administering acetylcholinesterase inhibitors?

To increase chances of lucid dreaming (by prolonging REM sleep) To treat Alzheimer’s disease, the Lewy body dementias and Parkinson’s disease. In these neurodegenerative conditions AChEIs are primarily used to treat the cognitive (memory and learning deficits mostly) symptoms of dementia.

Which is a drawback of early cholinesterase inhibitors?

Cholinesterase inhibitors can’t reverse Alzheimer’s disease or stop the destruction of nerve cells. These medications eventually lose effectiveness because dwindling brain cells produce less acetylcholine as the disease progresses.

How does acetylcholine affect blood pressure?

Acetylcholine (ACh) decreases blood pressure by stimulating endothelium nitric oxide-dependent vasodilation in resistance arterioles.

Why do cholinesterase inhibitors cause bradycardia?

Cholinesterase inhibitor medications can cause a cholinergic excess that can result in non-specific symptoms including gastrointestinal upset, diarrhea, and muscle cramps. These effects can theoretically also cause bradycardia by increasing vagal tone.

What drugs are acetylcholinesterase inhibitors?

Donepezil, rivastigmine and galantamine all prevent an enzyme called acetylcholinesterase from breaking down acetylcholine in the brain.

Why do acetylcholinesterase inhibitors cause bradycardia?

Because of their pharmacologic action, cholinesterase inhibitors may have vagotonic effects on the sinoatrial and atrioventricular nodes. This effect may manifest as bradycardia or heart block in patients both with and without underlying cardiac conduction abnormalities.

How do acetylcholinesterase inhibitors work?

Cholinesterase inhibitor drugs, inhibiting AChE activity, maintain ACh level by decreasing its breakdown rate. Therefore, they boost cholinergic neurotransmission in forebrain regions and compensate for the loss of functioning brain cells.