What genes activated by NF kb?

Several of these target genes, such as vimentin, laminin, collagenase and gelatinase, appear to involve NF-κB in the regulation of cell structure and micro-environment. Such an adaptation response may also serve to reduce cell stress, however, more data are required to evaluate a role for NF-κB in these processes.

What is the NFkb pathway?

Nuclear factor kappa B (NF-κB) is an ancient protein transcription factor (Salminen et al., 2008) and considered a regulator of innate immunity (Baltimore, 2009). The NF-κB signaling pathway links pathogenic signals and cellular danger signals thus organizing cellular resistance to invading pathogens.

What is the role of NF-kB?

NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

What happens when NF-kB is activated?

NF-κB target genes involved in inflammation development and progression. NF-κB is an inducible transcription factor. After its activation, it can activate transcription of various genes and thereby regulate inflammation.

How does NF-kB cause inflammation?

NF-κB target inflammation not only directly by increasing the production of inflammatory cytokines, chemokines and adhesion molecules, but also regulating the cell proliferation, apoptosis, morphogenesis and differentiation.

What is the function of NF-kB?

NF-κB regulates the expression of a large array of genes involved in different aspects of atherosclerotic pathogenesis. In vascular endothelial cells, NF-κB mediates induction of pro-inflammatory cytokines, chemotactic factors and adhesion molecules, thereby promoting monocyte recruitment and disease progression.

What cytokines does NF-kB activate?

NF-κB mediates the induction of pro-inflammatory cytokines, such as TNF-α, IL-1 and IL-6, in monocytes/macrophages.

How does NF-kB induce gene expression?

The cytokine tumor necrosis factor (TNF) initiates tissue inflammation, a process mediated by the NF-κB transcription factor. In response to TNF, latent cytoplasmic NF-κB is activated, enters the nucleus, and induces expression of inflammatory and anti-apoptotic gene expression programs.

What drugs inhibit NF-kB?

Several known NF-κB inhibitors were confirmed in this study, such as bortezomib, a proteasome inhibitor that blocks the NF-κB signaling pathway [22], and cantharidin, a natural product that reduces NF-κB protein levels in cells and inhibits invasion and metastasis of highly metastatic ovarian carcinoma cell line [23].

What cytokines does Nfkb activate?

What is the role of NFKB?

Is NF kB a transcription factor?

Rel or NF-kappaB (NF-kB) proteins comprise a family of structurally-related eukaryotic transcription factors that are involved in the control of a large number of normal cellular and organismal processes, such as immune and inflammatory responses, developmental processes, cellular growth, and apoptosis.