What drugs can be reversed by flumazenil?

Flumazenil has been administered in adults to reverse the effects of benzodiazepines in conscious sedation, general anesthesia, and the management of suspected benzodiazepine overdose.

For what drug overdose is flumazenil used?

Flumazenil is used to help you wake up after a surgery or medical procedure in which a benzodiazepine was used as a sedative. Flumazenil is also used to treat benzodiazepine overdose in adults.

Does flumazenil reverse sedation?

Flumazenil in a dose of 0.15 mg is a safe drug that reverses the sedative effect of midazolam.

Why is flumazenil not recommended?

Flumazenil lowers the seizure threshold and may lead to life-threatening seizures. It should be avoided or used with extreme caution in settings of benzodiazepine dependence, seizure disorder, cyclic antidepressant overdose, and elevated intracranial pressure.

When is flumazenil used?

Flumazenil injection is indicated for a complete or partial reversal of the sedative effects of benzodiazepines in conscious sedation and general anesthesia in adult and pediatric populations.

How is flumazenil given?

The recommended starting dose is 200 micrograms administered intravenously over 15 seconds. If the required level of consciousness is not obtained within 60 seconds, a further dose of 100 micrograms can be injected and repeated at 60-second intervals, up to a maximum dose of 1000 micrograms.

When should flumazenil be used?

What is the mechanism of action of flumazenil?

Clinical pharmacology Flumazenil, an imidazobenzodiazepine derivative, antagonizes the actions of benzodiazepines on the central nervous system. Flumazenil competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex.

What is the reversal agent for chloral hydrate?

Reversal of chloral hydrate overdose with flumazenil.

Is flumazenil used for benzo overdose?

Incremental intravenous bolus injections of flumazenil 0.1 to 0.3 mg are the most effective and well tolerated in the diagnosis and treatment of pure benzodiazepine overdose; additional boluses or an infusion (0.3 to 0.5 mg/h) can be given to prevent patients from relapsing into coma.

Can you give flumazenil?

Flumazenil was administered by a randomly selected route [0.2 mg followed 1 minute later by 0.3 mg i.v., sublingual (s.l.) or intramuscular (i.m.); or 1 mg followed 1 minute later by 1.5 mg per rectum (PR)]. Time to return to baseline respiratory functions was recorded (“time to reversal”).

How fast does flumazenil work?

The onset of action is about 1 to 2 minutes; 80% response occurs within the first 3 minutes. The peak effect is 6 to 10 minutes after administration. The duration ranges from 19 minutes to 50 minutes, depending on the dose and benzodiazepine plasma concentrations.