What drugs are antitumor agents?

What drugs are antitumor agents?

Antitumor antibiotic They are not the same as antibiotics used to treat bacterial infections. Rather, these drugs cause the strands of genetic material that make up DNA to uncoil, thereby preventing the cell from reproducing. Doxorubicin, mitoxantrone, and bleomycin are some examples of antitumor antibiotics.

Which enzyme used antitumor agent?

L-Asparaginase, LGlutaminase, L-Argininase, L-Methioninase are some of examples of enzymes that are used in cancer therapy that target specific amino acids resulting in disturbance of cancer cell proliferation without affecting normal cell metabolism.

What peptide is used as an antitumor agent?

Bovine lactoferrin (LfcinB) is a cationic peptide derived from lactoferrin, which can induce the production of cytokines so as to enhance host defence against the tumour. This is a way to restrain the growth of cancer through immune regulation [57].

How does Glutaminase enzyme act as antitumor drugs?

It is useful in the treatment of acute lymphocytic leukaemia [2], and exhibits its anticancer effect by depleting the L-glutamine from the cancerous cells, since these cells more avidly consume L-glutamine for their energy needs and proliferation than normal cells [3,4].

How does L asparaginase work?

All cells need a substance called asparagine to make proteins and create new cells. Asparaginase is an enzyme that breaks down asparagine. Unlike normal cells, ALL cells are unable to make their own asparagine. So asparaginase stops the cancer cells from dividing and growing.

What is peptide treatment?

Peptide therapy is the use of peptides in treatment to direct cells to perform the function specific to the peptide being used. Since our bodies naturally produce many kinds of peptides, there are many different types of peptide therapy, all of which are used to trigger a specific function within the body.

What are peptides and polypeptides?

A peptide is a short chain of amino acids (typically 2 to 50) linked by chemical bonds (called peptide bonds). A longer chain of linked amino acids (51 or more) is a polypeptide. The proteins manufactured inside cells are made from one or more polypeptides.

Which are antitumor antibiotics?

The antitumor antibiotics consist of dactinomycin, adriamycin, bleomycin, mithramycin, and mitomycin-C. They function as cell-cycle-nonspecific DNA intercalating agents, interfering with DNA and RNA synthesis [8,21]. Penetration of the blood–brain barrier is poor.

When are antitumor antibiotics used?