What drug causes prolonged QT?
What drug causes prolonged QT?
The most potent QT-prolonging medications are antiarrhythmic agents, particularly amiodarone, dofetilide, quinidine, and sotalol, with quinidine possibly having the most torsadogenic potential.
What medications should be avoided with long QT syndrome?
Table 1
| Drugs to be avoided in patients with c-long QT syndrome | |
|---|---|
| α1-blocker | Alfuzosin |
| Bronchodilator/decongestant | Albuterol, Salmeterol, Metaproterenol, Terbutaline, Metaproterenol, Levalbuterol, Ephedrine, Phenylpropanolamine, Pseudoephedrine |
| Cholinesterase inhibitor | Galantamine |
| CNS stimulant | Amphetamine |
What do you give for QT prolongation?
Beta blockers. These heart drugs are standard therapy for most patients with long QT syndrome. They slow the heart rate and make long QT episodes less likely. Beta blockers used to treat long QT syndrome include nadolol (Corgard) and propranolol (Inderal LA, InnoPran XL).
Which opioid causes QT prolongation?
Some opioids such as fentanyl, tramadol and oxycodone have intermediate risk. They usually produce a long QT interval and occasionally arrhythmia in high doses. Others such as morphine and buprenorphine are low-risk and in routine doses they seldom create a long QT interval and arrhythmia.
Does omeprazole prolong QTc?
The most commonly used QT prolonging drugs in medical wards were, omeprazole (25.9%), furosemide (13.8%), esomeprazole (13.8%), metronidazole (11.1%), azithromycin (4.7%), clarithromycin (4.5%), ciprofloxacin (4.1%), domperidone (3.1%), ondansetron (2.5%), moxifloxacin (2.1%), fluconazole (2.1%), metoclopramide (1.4%).
Does propofol prolong QT?
PROPOFOL is a widely used anesthetic drug and does not prolong corrected QT interval as much as other anesthetic agents, including midazolam. 1Propofol is also used for induction and maintenance of general anesthesia, even in patients with either congenital or acquired long QT syndrome.
What are QT drugs?
Drugs Causing QT Prolongation
- Chlorpromazine.
- Haloperidol.
- Droperidol.
- Quetiapine.
- Olanzapine.
- Amisulpride.
- Thioridazine.
Can you give Zofran with prolonged QTc?
The use of a single 32 mg intravenous dose of ondansetron should be avoided. New information indicates that QT prolongation occurs in a dose-dependent manner, and specifically at a single intravenous dose of 32 mg.
Does tramadol prolong QTc?
Conclusion: Tramadol produces QTc interval prolongation in good correlation with plasma drug concentrations; renal failure is a risk factor for higher concentration and QT prolongation by tramadol.
Does oxycodone increase QTc?
Higher oxycodone dose was also associated with longer QTc (R(2) = 0.21; P = 0.02). A 100 mg higher oxycodone dose was associated with a 10 ms(1/2) (95% CI 2-19) longer QTc. Neither morphine nor tramadol dose was associated with the QTc.
