What does the pancreatic acini secrete?
What does the pancreatic acini secrete?
Ninety percent of the pancreas is composed of acinar cells which secrete digestive enzymes such as trypsin, chymotrypsin, and amylase for digestion of food in the small intestine.
What is the function of CCK?
CCK cells are concentrated in the proximal small intestine, and hormone is secreted into the blood upon the ingestion of food. The physiological actions of CCK include stimulation of pancreatic secretion and gallbladder contraction, regulation of gastric emptying, and induction of satiety.
How is pancreas function tested?
During a pancreatic function test, a tube is inserted through the nose or throat into the stomach and small intestine. Secretin is given to the patient by injection into a vein. After a certain amount of time, samples of fluid are taken from the small intestine through the tube and sent to a lab to test for a response.
What is CCK in blood test?
The secretin-induced rapid flow of water results in lower and often unreliable enzyme concentrations. CCK also induces gallbladder contraction and the release of bile, which may further dilute enzyme concentrations….
| Secretin-cholecystokinin test | |
|---|---|
| Purpose | assess the function of both the pancreas and gall bladder |
What cells secrete trypsin?
Trypsinogen is the inactive preform (or zymogen) of trypsin, a proteolytic enzyme synthesized exclusively by pancreatic acinar cells and normally secreted into the duodenum where it is activated, with only minimal amounts reaching the circulation.
What is the difference between CCK and secretin?
The key difference between secretin and cholecystokinin is that the secretin is a peptide hormone produced by S cells of the duodenum and jejunum while the cholecystokinin is another peptide hormone secreted by I cells of the duodenum.
What is the CCK target and its response?
Circulating CCK binds to specific CCK-1 receptors on the gallbladder, pancreas, smooth muscle of the stomach, and peripheral nerves to stimulate gallbladder contraction and pancreatic secretion, regulate gastric emptying and bowel motility, and induce satiety.
How is CCK measured?
CCK concentrations expressed as CCK-8 equivalents in pmol/L (fmol/mL) are calculated using non-linear regression analysis. The sensitivity of the assay is sufficient to detect concentrations as low as 2 picomolar. Therefore, we use plasma samples of 2 mL in order to detect ~1 picomolar concentrations of blood CCK.
What does CCK and secretin do?
Secretin and CCK also control the production and secretion of bile. Secretin stimulates the flow of bile from the liver to the gallbladder. CCK stimulates the gallbladder to contract, causing bile to be secreted into the duodenum, as shown below.
Which enzyme activates trypsin?
enterokinase
Trypsin is a serine protease of the digestive system produced in the pancreas as an inactive precursor, trypsinogen. It is then secreted into the small intestine, where enterokinase proteolytic cleavage activates it into trypsin.
