What does Sbecd stand for?

Background. The disposition of sulfobutylether-b- cyclodextrin (SBECD), the solubilizing excipient in intravenous (IV) voriconazole, was assessed in seven male subjects with end-stage renal disease on hemodial- ysis and six subjects with normal renal function. Methods.

Is voriconazole nephrotoxic?

Hepatotoxicity was more common in voriconazole group (OR = 1.60, 95% CI = 1.17–2.19, P = 0.003) whereas its pooled risk of nephrotoxicity was about half of the composite of other five antifungal agents (OR = 0.46, 95% CI = 0.26–0.84, P = 0.01).

What is Betadex sulfobutyl ether sodium?

Betadex Sulfobutyl Ether Sodium (BSES) is a cyclodextrin that is used as a drug delivery solution. In a USP monograph the purity analysis requirements of this substance is described. The ALEXYS Analyzer for BSES meets these requirements.

What is Sulfobutylether beta cyclodextrin?

SBE-β-CD is a sulfobutylether β-cyclodextrin derivative used as an excipient or a formulating agent to increase the solubility of poorly soluble agents. In Vitro. SBE-β-CD is a chemically modified β-CD that is a cyclic hydrophilic oligosaccharide which is negatively charged in aqueous media.

Is Remdesivir nephrotoxic?

Based on ARF cases reported in VigiBase, and despite the caveats inherent to COVID-19 circumstances, we detected a statistically significant pharmacovigilance signal of nephrotoxicity associated with remdesivir, deserving a thorough qualitative assessment of all available data.

Can voriconazole cause Aki?

Acute kidney injury (AKI), assessed by RIFLE criteria, was more frequent in the fluconazole vs. the caspofungin group (p < 0.01); incidence of AKI in the voriconazole group was not significantly different than found in the other two groups.

How safe is voriconazole?

Voriconazole has rarely caused very serious (possibly fatal) liver disease. Tell your doctor right away if you develop symptoms of liver disease, such as: nausea/vomiting that doesn’t stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine. A very serious allergic reaction to this drug is rare.

What is Betadex Sulfobutyl?

Sulfobutyl ether β-cyclodextrin sodium (also called Betadex sulfobutyl ether sodium) is a chemically modified β-cyclodextrin used as drug delivery system.

What is Betadex?

Betadex, C42H70O35, also known as beta-cyclodextrin, is a chemical reagent and complexing agent often used in pharmaceutical science.

Will remdesivir shut down your kidneys?

We found 2,922 reports with remdesivir registered in FAERS for COVID-19. Among these, 493 renal and urinary adverse effects (16.9%) were reported. The most frequent events were acute kidney injury (338; 11.6%), renal impairment (86; 2.9%), and renal failure (53; 1.8%).