What does Pseudoporphyria mean?

Pseudoporphyria is a bullous photosensitivity that clinically and histologically mimics porphyria cutanea tarda. The difference is that no abnormalities in urine or serum porphyrin is noted on laboratories.

What causes Pseudoporphyria?

Pseudoporphyria is generally due to drugs or other agents which interact with sunlight to cause a phototoxic reaction in the skin. These include: Non steroidal anti-inflammatory drugs (NSAIDs) e.g. naproxen, oxaprozin, ketoprofen, mefenamic acid, diflunisal 5) and celecoxib. Antibiotics – doxycyline, nalidixic acid.

Is Pseudoporphyria treatable?

Pseudoporphyria associated with nonhemodialyzed renal insufficiency, successfully treated with oral N-acetylcysteine. Case Rep Dermatol Med 2013; 2013:271873.

What is drug induced Pseudoporphyria?

Pseudoporphyria (PP) is used to describe a photodistributed bullous disorder with clinical and histologic features of porphyria cutanea tarda (PCT) but without accompanying biochemical porphyrin abnormalities. Medications, excessive sun and ultraviolet radiation exposure, have all been reported to develop PP.

Can chlorophyll cause Pseudoporphyria?

To conclude, we emphasize chlorophyll supplementation as a cause of pseudoporphyria, with potential persistent symptoms after cessation.

How do you treat EPP?

In 2019, the Food and Drug Administration (FDA) approved Scenesse (afamelanotide) for the treatment of adult patients with EPP. Scenesse is an injectable implant and works by increasing skin pigmentation which provides protection and improves sun tolerance.

What is porphyria cutanea tarda?

Summary. Porphyria cutanea tarda (PCT) is a rare disorder characterized by painful, blistering skin lesions that develop on sun-exposed skin (photosensitivity). Affected skin is fragile and may peel or blister after minor trauma. Liver abnormalities may also occur.

What happens when you have porphyria?

During an attack, you may experience dehydration, breathing problems, seizures and high blood pressure. Episodes often require hospitalization for treatment. Long-term complications with recurrent acute attacks may include chronic pain, chronic kidney failure and liver damage.