What does Proteus mirabilis in urine mean?

Proteus mirabilis (PM) is a Gram-negative rod-shaped bacterium and widely exists in the natural environment, and it is most noted for its swarming motility and urease activity. PM is the main pathogen causing complicated urinary tract infections (UTIs), especially catheter-associated urinary tract infections.

What causes Proteus mirabilis infection?

It is thought that the majority of P. mirabilis urinary tract infections (UTI) result from ascension of bacteria from the gastrointestinal tract while others are due to person-to-person transmission, particularly in healthcare settings (1).

Is Proteus mirabilis serious?

Proteus is found abundantly in soil and water, and although it is part of the normal human intestinal flora (along with Klebsiella species, and Escherichia coli), it has been known to cause serious infections in humans.

How do I get rid of Proteus mirabilis?

For hospitalized patients, therapy consists of parenteral (or oral once the oral route is available) ceftriaxone, quinolone, gentamicin (plus ampicillin), or aztreonam until defervescence. Then, an oral quinolone, cephalosporin, or TMP/SMZ for 14 days may be added to complete treatment.

What is the best antibiotic for Proteus mirabilis?

mirabilis. The tested antibiotics included: ciprofloxacin, ceftriaxone, nitrofurantoin, and gentamicin. Of them, ciprofloxacin showed the highest activity. Up to 93% reduction in biofilm formation was achieved using a concentration of ciprofloxacin corresponding to 1/2MIC.

Is Proteus mirabilis a complicated UTI?

Proteus mirabilis is a common pathogen responsible for complicated urinary tract infections (UTIs) that sometimes causes bacteremia. Most cases of P. mirabilis bacteremia originate from a UTI; however, the risk factors for bacteremia and mortality rates from P.

What does Proteus mirabilis smell like?

Rotten cooked fishy odor
Rotten cooked fishy odor: Proteus mirabilis produces a very distinct fishy odour. On Salmonella-Shigella (SS) agar, Proteus usually smells like “rotten cooked fish”.

What antibiotics are used to treat Proteus mirabilis?

The most appropriate treatment for P. mirabilis may be aminoglycosides, carbapenems (except imipenem), and 3rd generation cephalosporins. Recent P. mirabilis isolates were also mostly susceptible to augmentin, ampicillin-sulbactam, and piperacillin/tazobactam.

What kills Proteus mirabilis naturally?

When the Proteus bacteria were exposed to high concentrations of cranberry powder, the researchers saw two interesting effects. First, just as in E. coli, the bacteria’s ability to swim or swarm across an agar plate embedded with cranberry powder was almost completely eliminated.

What are the signs and symptoms of Proteus mirabilis?

Proteus mirabilis commonly causes urinary tract infections and the formation of stones….Common symptoms include:

  • Frequency of urination.
  • Pyuria (presence of white blob cells in the urine)
  • Cystitis (bladder infection)
  • Back pain.
  • Urgency.
  • Hematuria (presence of red blood cells in the urine)

What is Proteus mirabilis susceptible to?

P mirabilis is likely to be sensitive to ampicillin; broad-spectrum penicillins (eg, ticarcillin, piperacillin); first-, second-, and third-generation cephalosporins; imipenem; and aztreonam. P vulgaris and P penneri are resistant to ampicillin and first-generation cephalosporins.

What antibiotic is Proteus mirabilis resistant to?

P. mirabilis is naturally resistant to several antibiotics including colistin and shows reduced susceptibility to imipenem. However higher levels of resistance to imipenem commonly occur in P.