What does Pnipam stand for?

Poly(N-isopropylacrylamide) (variously abbreviated PNIPA, PNIPAAm, NIPA, PNIPAA or PNIPAm) is a temperature-responsive polymer that was first synthesized in the 1950s. It can be synthesized from N-isopropylacrylamide which is commercially available.

How do you make Pnipam hydrogel?

PNIPAM hydrogel can be prepared by using precipitation polymerization. The NIPAM monomer (2.5 g), MBAAm cross-linker (0.025 g), and various amounts of sodium chloride should be dissolved in 45 g of distilled water in a a reflux condenser, a Teflon paddle stirrer, and a nitrogen gas inlet.

Is nipam hydrophilic?

Similarly, PNIPAM is not completely hydrophilic – it is has hydrophilic and hydrophobic domains above and below the LCST.

Is Pnipam FDA approved?

Magnetite, PNIPAm and FA are all FDA-approved and relatively safe materials and their combination also resulted in a safe drug delivery vehicle31,32,33.

Is nipam biodegradable?

A series of novel TBH scaffolds have been designed, synthesized and characterized. The TBHs were composed of PNIPAM as a thermoresponsive unit, PCLDMA as a hydrolytically degradable and hydrophobic unit, and BACy as a reducibly degrading and hydrophilic unit.

Is Pnipam water soluble?

PNIPAM is soluble in organic solvents, such as chloroform, acetone, methanol, and various other alcohols. It is also soluble in water, as long as the solution is kept reasonably cold.

What is Lcst of Pnipam?

Poly(N-isopropylacrylamide), PNIPAM, is a thermoresponsive polymer widely known for its lower critical solution temperature (LCST) phenomenon at 32 °C in aqueous solutions.

What is LCST of Pnipam?

What is LCST and Ucst?

Partially miscible polymer solutions often exhibit two solubility boundaries, the upper critical solution temperature (UCST) and the lower critical solution temperature (LCST), which both depend on the molar mass and the pressure.

What do you mean by UCST?

The upper critical solution temperature (UCST) or upper consolute temperature is the critical temperature above which the components of a mixture are miscible in all proportions.

What is CST method in Physical Pharmaceutics?

Partially miscible liquids become more soluble with the increase in temperature and at a certain temperature they are completely miscible. This temperature is known as the critical solution temperature (CST) or consolute temperature. The temperature above the phase gets affected by the addition of impurities.