What does interferon protein do?

Interferons are proteins that are part of your natural defenses. They tell your immune system that germs or cancer cells are in your body. And they trigger killer immune cells to fight those invaders. Interferons got their name because they “interfere” with viruses and keep them from multiplying.

What are interferon inducible genes?

Viperin (virus inhibitory protein, endoplasmic reticulum-associated, IFN-inducible) is an Interferon stimulated gene (ISG), which is induced by type I, II, and III IFNs or after infection with a broad range of DNA and RNA viruses.

What is the difference between type 1 and type 2 interferons?

The key difference between type I and type II interferon is that type I interferon binds with a cell surface receptor called interferon-α/β receptor (IFNAR) while type II interferon binds with a specific receptor called IFN-γ receptor (IFNGR) complex.

What are the 3 classes of interferons?

There are three types of interferons (IFN), alpha, beta and gamma. IFN-alpha is produced in the leukocytes infected with virus, while IFN-beta is from fibroblasts infected with virus. IFN-gamma is induced by the stimulation of sensitized lymphocytes with antigen or non-sensitized lymphocytes with mitogens.

What is alpha interferon used for?

Interferon alfa-2b injection is used to treat hepatitis B and C, lymphoma (lymph node cancer), malignant melanoma (skin cancer), genital warts, hairy cell leukemia (blood cell cancer), and Kaposi sarcoma (AIDS-related tumor). Interferons are substances produced by cells in the body to help fight infections and tumors.

What is the function of interferon alpha?

The main function of the IFN-alpha 1 is to alert the organism in case of viral infection by detection of abnormal double stranded DNA, but also to inhibit virus multiplication by action on the translation in infected cells.

What is interferon alpha used for?

Interferon alfa-2b injection is used to treat hepatitis B and C, lymphoma (lymph node cancer), malignant melanoma (skin cancer), genital warts, hairy cell leukemia (blood cell cancer), and Kaposi sarcoma (AIDS-related tumor).

What are the risks of interferons?

Interferon and ribavirin side effects

  • neutropenia (low levels of white blood cells)
  • thrombocytopenia (low platelet count)
  • anemia.
  • infections.
  • vision problems, such as retinopathy (disease of the retina), that can cause vision loss.
  • aggravation of autoimmune disorders, such as rheumatoid arthritis or psoriasis.

Can interferon cause liver damage?

Interferon beta is a well known cause of mild hepatic injury that occasionally can lead to severe liver injury with jaundice.