What does high IgG avidity mean?

IgG avidity assays measure the binding strength between IgG antibodies and virus that can help distinguish a primary CMV infection from a past infection. Following primary CMV infection, IgG antibodies have low binding strength (low avidity) then over 2-4 months mature to high binding strength (high avidity).

What happens if cytomegalovirus IgG is high?

If your results are higher, it may also mean that you have a connective tissue autoimmune disease, such as rheumatoid arthritis or systemic lupus erythematosus. If your immune system is weakened, you may have lower results even with an active infection.

When should I do my avidity test?

CMV IgG avidity testing is now a proven, valuable laboratory tool for diagnosing primary CMV infection during pregnancy. Low avidity indicates primary infection within the preceding 3 to 4 months, with an increased risk of intrauterine transmission to the fetus/newborn.

What does positive cytomegalovirus IgM mean?

Positive CMV IgM results indicate a recent infection (primary, reactivation, or reinfection). IgM antibody responses in secondary (reactivation) CMV infections have been demonstrated in some CMV mononucleosis patients, in a few pregnant women, and in renal and cardiac transplant patients.

What does IgG positive mean?

The presence of IgG suggests that the infection happened weeks to months in the past. It also suggests that you may no longer be infectious. IgG indicates that you may have some immunity to the virus, though you may not. How much it might protect you from getting sick with COVID-19 in the future is unknown.

Is it good to be CMV positive?

The majority of children born who experience a CMV infection before birth are healthy and normal. However, 10 to 15% may have complications such as hearing loss, neurological abnormalities, or decreased motor skills. Infants who are infected with CMV after they are born rarely experience any long-term complications.

What’s avidity mean?

keen eagerness
Definition of avidity 1 : the quality or state of being avid: a : keen eagerness. b : consuming greed.