What does FGFR stand for?

FGFR stands for fibroblast growth factor receptor. FGFR helps cells grow, survive, and multiply. In certain types of cancer, like in some cases of bladder cancer, the gene that controls FGFR can change or mutate (known as an FGFR alteration).

What is the function of FGFR?

The fibroblast growth factor receptors (FGFRs) regulate important biological processes including cell proliferation and differentiation during development and tissue repair.

What is FGFR amplification?

FGFR1 Amplification is an inclusion criterion in 8 clinical trials for non-small cell lung carcinoma, of which 6 are open and 2 are closed. Of the trials that contain FGFR1 Amplification and non-small cell lung carcinoma as inclusion criteria, 2 are phase 1 (1 open) and 6 are phase 2 (5 open) [5].

What is Fgfr mutation?

A single mutation in the FGFR3 gene has been shown to cause Muenke syndrome, which is a condition that causes craniosynostosis, leading to a misshapen head and distinctive facial features. Additional signs and symptoms can include hearing loss, subtle hand and foot abnormalities, and developmental delay.

How many FGFR are there?

The human fibroblast growth factor receptor (FGFR) family consists of four members: FGFR1 to FGFR4.

How do you test FGFR?

An FDA-approved companion diagnostic test helps identify patients whose tumors have certain FGFR genetic alterations. The test detects certain clinically actionable FGFR genetic alterations from formalin-fixed paraffin-embedded urothelial tumor tissue.

What is FGFR test?

Genetics Test Information This test is an FDA-approved assay for the evaluation of somatic mutations and fusions in the FGFR3 and FGFR2 genes to identify urothelial carcinoma patients that may be eligible for treatment with FGFR-targeted therapies such as Balversa (erdafitinib).

Where are FGFR found?

One particular isoform of the FGFR3 protein is found specifically in cells that line the surfaces of the body (epithelial cells), including the cells that form the outermost layer of skin, called the epidermis.

What is FGFR mutation?