What does drug selectivity mean?

Selectivity will be used to describe the ability of a drug to affect a particular population, i.e., gene, protein, signaling pathway, or cell, in preference to others. For example a selective drug would have the ability to discriminate between, and so affect only one cell population, and thereby produce an event.

What is selectivity in drug discovery?

The antithesis of drug selectivity, namely polypharmacology (whereby a given ligand is designed to activate more than one target) may also furnish useful therapeutic profiles, especially in the central nervous system. From: Reference Module in Biomedical Sciences, 2021.

What is meant by target specificity and selectivity Why is it important?

1) Target specificity and selectivity refers to the ability of a drug to distinguish between different molecular targets, whether these targets be totally different in nature or slight variations of the same target. For example, drugs can show specificity or selectivity between different types and subtypes of receptor.

What is the difference between sensitivity and selectivity?

Selectivity is the quality of a response that can be achieved without interference for any other substance. Sensitivity is how low can you detect the substance of interest. The best analytical method offers the highest sensitivity and highest selectivity.

Does selectivity indicate safety?

Selectivity is an important attribute of effective and safe drugs, and prediction of in vivo target and tissue selectivity would likely improve drug development success rates.

What are drug targets examples?

Most drug targets are members of families of proteins that are related phylogenetically. Examples include G-protein coupled receptors (GPCRs), protein kinases, nuclear hormone receptors, serine proteases, and ion channels.

What is difference between specificity and selectivity?

It is important to understand that the term specificity is used to tell something about the method’s ability responding to one single analyte only, while selectivity is used when the method is able to respond to several different analytes in the sample.

What happens if drug is not selective?

Selectivity is the degree to which a drug acts on a given site relative to other sites. Relatively nonselective drugs affect many different tissues or organs. For example, atropine, a drug given to relax muscles in the digestive tract, may also relax muscles in the eyes and in the respiratory tract.

What is sensitivity and selectivity?

Sensitivity refers to a radar detector’s ability to pick up police signals at the greatest distance. Selectivity refers to the detector’s ability to filter out signals that are not true police signals, yet operate on the same frequencies as police radar (i.e. security alarms, garage doors, automatic doors, etc.).