What does Dectin-1 bind to?

Dectin-1 is a type II transmembrane protein which binds β-1,3 and β-1,6 glucans. It is expressed on most cells of the innate immune system and has been implicated in phagocytosis as well as killing of fungi by macrophages, neutrophils and dendritic cells.

Where is Dectin-1 found?

myeloid cells
Dectin-1 belongs to the hemITAM family and can be found in the plasma membrane of various myeloid cells, including DCs, monocytes, and macrophages, as well as B cells. Activation of dectin-1 by fungal cell wall β-glucans stimulates phagocytosis, the production of ROS, and NFκB-mediated cytokine secretion.

What does Dectin 1 recognize?

Dectin-1 specifically recognizes soluble and particulate β(1→3)- and/or β(1→6)-linked glucans27; these are carbohydrate polymers with immunomodulatory activity that are found mainly in the cell walls of fungi, but also in plants and some bacteria.

What are C type lectin receptors?

C-type lectin receptors (CLRs) are a large family of transmembrane and soluble receptors that contain one or more carbohydrate-recognition domain able to recognize a wide variety of glycans on pathogens or on self-proteins. The hallmark of classical CLRs is the dependence on Ca2+ for glycan recognition.

What do scavenger receptors do?

Overall, scavenger receptors identify and remove unwanted entities, through the recognition of modified self molecules (for example, apoptotic cells, mineral-laden debris or damaged proteins) or through the recognition of non-self molecules (for example, microorganisms or foreign particles)16,20,21,22,23,24,25,26,27.

What type of receptor is Dectin 1?

Dectin-1 is a natural killer (NK)-cell-receptor-like C-type lectin that is thought to be involved in innate immune responses to fungal pathogens. This transmembrane signalling receptor mediates various cellular functions, from fungal binding, uptake and killing, to inducing the production of cytokines and chemokines.

How do C-type lectin receptors work?

C-type lectin receptors (CLRs) expressed by dendritic cells are crucial for tailoring immune responses to pathogens. Following pathogen binding, CLRs trigger distinct signalling pathways that induce the expression of specific cytokines which determine T cell polarization fates.

Where are scavenger receptors found?

Scavenger receptors are mainly found on myeloid cells and other cells that bind to numerous ligands, primarily endogenous and modified host-molecules together with pathogen-associated molecular patterns(PAMPs), and remove them.

What are scavenger cells?

Definitions of scavenger cell. a cell that engulfs and digests debris and invading microorganisms. synonyms: phagocyte.