What does CGH array stand for?

Array comparative genomic hybridization
Array comparative genomic hybridization. Array comparative genomic hybridization (also microarray-based comparative genomic hybridization, matrix CGH, array CGH, aCGH) is a molecular cytogenetic technique for the detection of chromosomal copy number changes on a genome wide and high-resolution scale.

Is CGH same as microarray?

These very small changes are often called microdeletions and microduplications. Array CGH is also sometimes called CGH array, aCGH or simply a microarray.

What does ARR 1/22 x2 mean?

Female: arr (1-22,x)x2. Comments: CMA is indicated for patients with normal chromosome analysis or: unexplained developmental delay or mental retardation, dysmorphic features or congenital anomalies, autism spectrum disorders, seizures, or a clinical presentation suggestive of a chromosomal syndrome.

How do you sequence a whole genome?

Sequencing technologies are unable to sequence the entire human genome at once. Thus, the genome must be broken into smaller chunks of DNA, sequenced and then put back together in the correct order using bioinformatics approaches.

What is CGH microarray testing?

Array CGH (also known as microarray, or chromosome microarray (CMA)) is an ultra-high resolution way of objectively and quantitatively detecting whether a patient’s DNA has losses (deletions) or gains (duplications, triplications etc) which are pathogenic and therefore explain their clinical problems.

How does SNP array differ from array CGH?

A typical clinical CGH array contains a few hundred thousand probes, while the number of probes on research CGH arrays may reach into the millions. Single nucleotide polymorphism (SNP) arrays use DNA probes that derive from regions in the genome that show differences between individuals at a single base pair site.

How do you label a karyotype?

Determine the sex chromosomes, whether they are “XX” or “XY.” If they are “XX,” the subject is a female; “XY,” the subject is a male. Write this combination next to the number after a comma. In a normal woman, this will look like this “46, XX.” Note any irregularities in the karyotype.