What does CD57 positive mean?
What does CD57 positive mean?
Similarly, CD57 expression seems to identify the final stages of peripheral NK cell maturation; its expression increases with age and is associated with chronic infections, particularly human cytomegalovirus infection.
Why is CD57 low in Lyme?
If the count is low, the cause of the symptoms may be from Borrelia burgdorferi. If the count is normal, the cause may still be from Lyme disease, but it could also be due to some other agent. The CD57 is expressed on both natural killer (NK) cells and T lymphocytes.
What should your CD57 be?
The standard normal range for the absolute CD57 NK count is 60 to 360 cells per microliter of blood. This wide range was established based upon test results of hundreds of healthy patients.
What is low CD57?
The Lyme Disease CD57 HNK1 test is used to aid in the diagnosis of Lyme Disease as well as to monitor treatment. Lyme Disease tends to suppress a person’s immune system and many people with Lyme have shown a low count for the CD57 Lymphocyte. Typically a CD57 count below 60 is indicative of Lyme Disease.
What is a CD 57?
CD57 is a Marker of NK Cell Differentiation HNK-1/Leu-7/CD57 was initially believed to be uniquely expressed on NK cells – and was used to define this population (1, 3) – although it was soon apparent that CD57 was expressed only on a subset of functionally distinct NK cells (4).
Do NK cells express CD57?
A total of 30% to 60% of CD56dimCD16bright NK cells in healthy adults express CD57, which is not expressed on immature CD56bright NK cells. Fetal and newborn NK cells do not express or express low amounts of CD57,23 and CD57 expression on NK cells increases with age.
What is CD56 a marker for?
CD56 is the archetypal phenotypic marker of natural killer cells but can actually be expressed by many more immune cells, including alpha beta T cells, gamma delta T cells, dendritic cells, and monocytes.