What does C-met stand for?

Biomarker Abbreviation: c-MET. Definition: also known as mesenchymal epithelial transition factor (MET) or hepatocyte growth factor receptor (HGFR) – a proto-oncogene active in cell signaling, c-MET promotes cancer cell growth and multiplication.

What is a C-met test?

Refrigerated. Clinical & Interpretive. Clinical Information. c-Met, a cell surface receptor tyrosine kinase, regulates cellular proliferation, migration, and differentiation during development. Increased expression of c-Met has been shown to correlate with poor prognosis in nonsmall cell carcinomas of the lung.

What is the difference between C-met and MET?

The MET gene is located on chromosome 7q21–q31 and is approximately 125 kb long with 21 exons. c-MET is a heterodimer composed of a 50-kDa highly glycosylated alpha-chain subunit and 145-kDa beta-chain.

Where is C-met expressed?

The protein product of this gene is the c-MET tyrosine kinase. This cell surface receptor is expressed in epithelial cells of many organs, including the liver, pancreas, prostate, kidney, muscle and bone marrow, during both embryogenesis and adulthood [Comoglio et al. 2008].

What does MET stand for gene?

Mesenchymal Epithelial Transition MET is a prototypical receptor tyrosine kinase. Its ligand is Hepatocyte Growth Factor (HGF). MET alterations are drivers of human cancer.

What does MET stand for in biology?

One metabolic equivalent (MET) is defined as the amount of oxygen consumed while sitting at rest and is equal to 3.5 ml O2 per kg body weight x min.

What is c-Met overexpression?

C-MET overexpression as a resistance biomarker to epidermal growth factor receptor tyrosine kinase inhibitors in EGFR-mutant non-small cell lung cancer.

How do tumors metastasize?

Metastatic tumors (metastases) can occur in three ways: They can grow directly into the tissue surrounding the tumor. Cancer cells can travel through your bloodstream to distant locations in your body. Cancer cells can travel through your lymph system to nearby or distant lymph nodes.

What does MET mutation mean?

Mutated (changed) forms of the MET gene may cause abnormal cells to grow and spread in the body. Mutations in the MET gene have been found in an inherited condition called hereditary papillary renal carcinoma (HPRC). Patients with HPRC have an increased risk of a type of kidney cancer called papillary renal carcinoma.

What does MET stand for in oncology?

The mesenchymal epithelial transition factor receptor (MET) is a potential therapeutic target in a number of cancers, including non-small cell lung cancer (NSCLC).

What does MET measure?

Abstract. One metabolic equivalent (MET) is defined as the amount of oxygen consumed while sitting at rest and is equal to 3.5 ml O2 per kg body weight x min.