What does Alpha 1 proteinase inhibitor do?
What does Alpha 1 proteinase inhibitor do?
Alpha-1 proteinase inhibitor injection, also called alpha 1-PI, is used to treat a certain type of emphysema (a lung condition). The emphysema is caused by the lack of a protein called alpha 1-antitrypsin (AAT) in the body. This medicine replaces the protein when the body does not produce enough.
What is Aralast used for?
This medication is used to treat lung problems (emphysema) caused by a certain inherited disease (alpha-1-proteinase inhibitor deficiency). In people with this condition, lung damage is caused by elastase, a natural substance that the body needs to kill bacteria in the lungs.
How is Aralast administered?
The recommended dosage of Aralast™ is 60 mg/kg body weight administered once weekly by intravenous infusion. Each vial of Aralast™ has the functional activity, as determined by inhibition of porcine pancreatic elastase, stated on the label.
What is the function of alpha-1-antitrypsin?
Alpha-1-antitrypsin (AAT) is a protein produced in the liver that protects the body’s tissues from being damaged by infection-fighting agents released by its immune system. In alpha-1 antitrypsin deficiency, the body’s normal production of AAT is reduced, resulting in the destruction of sensitive lung tissue.
What is antitrypsin deficiency?
Summary. Alpha-1 antitrypsin deficiency (AAT deficiency) is an inherited condition that raises your risk for lung and liver disease. Alpha-1 antitrypsin (AAT) is a protein that protects the lungs. The liver makes it. If the AAT proteins aren’t the right shape, they get stuck in the liver cells and can’t reach the lungs …
How long is an Aralast infusion?
Ensure a 5 micron in-line filter is always used during the infusion. Administer Glassia at room temperature and within 3 hours of entering a vial. Using an appropriate intravenous administration set, administer Glassia at a rate not greater than 0.2 mL/kg/minute; the infusion will take approximately 15 minutes.
Who makes Aralast?
1. Aralast® NP prescribing information. Westlake Village, CA: Baxalta US Inc.: Revised September 2016.
How long is Aralast infusion?
Using an appropriate intravenous administration set, administer Glassia at a rate not greater than 0.2 mL/kg/minute; the infusion will take approximately 15 minutes. Continuously monitor the patient’s vital signs throughout the infusion.
How do you mix Aralast?
Reconstitution
- Use aseptic technique.
- Allow ARALAST NP and diluent to reach room temperature before reconstitution.
- Remove caps from the diluent and product vials.
- Swab the exposed stopper surfaces with alcohol.
- Remove cover from one end of the double-ended transfer needle.
What would happen if the alpha-1 antitrypsin of a person is being inhibited or deactivated?
The rare disorder disorder called alpha-1 antitrypsin deficiency (Alpha-1) can lead to potentially life-threatening lung and liver diseases, including emphysema and cirrhosis. It affects males and females equally. Treatment depends upon what type of illness is caused by Alpha-1.
What does alpha-1 do to the heart?
Thus, unlike what can be seen with some Gq-coupled receptors, α1-ARs protect the heart by activating an adaptive or physiologic hypertrophy, preventing cardiac myocyte death, augmenting contractile function in heart failure and inducing preconditioning (section IV).
