What do the IgG subclasses do?

Each IgG subclass plays a slightly different role in protecting the body against infection, so a person lacking a specific IgG subclass will be vulnerable to certain kinds of infections but not others. There are over 400 different types of PI, each with its own characteristics and challenges.

Does IgG have subclasses?

IgG is composed of four subclasses: IgG1, IgG2, IgG3, and IgG4 [1-9]. The structure, genetics, and function of the IgG subclasses are reviewed in this section.

What is IgG subclass deficiency?

IgG subclass deficiency is defined as the decrease of one or more subclasses of IgG antibodies with normal or near normal levels of other immunoglobulin classes.

What is the function of IgA?

Immunoglobulin A (IgA) is the most abundant type of antibody in the body, comprising most of the immunoglobulin in secretions and a significant amount of circulating immunoglobulin. In secretions, it serves to protect the mucosal tissues from microbial invasion and maintain immune homeostasis with the microbiota.

What does IgG subclass 4 mean?

Immunoglobulin subclass 4 (IgG4)-associated diseases are an increasingly recognized group of autoimmune diseases,1,2 which are characterized by sclerosis and lymphoplasmocytic infiltration of affected organs with IgG4-positive cells.

What is IgG1 isotype?

The human IgG1 isotype control antibody is purified from human myeloma serum and is of unknown specificity. This antibody is suitable for use as a non-targeting isotype control in various in vitro and in vivo studies.

What does high IgG subclass 4 mean?

What does it mean if your Immunoglobulin Subclass 4 result is too high? The presence of high serum IgG4 levels is considered a biomarker for IgG4 related diseases. IgG4 related diseases includes disorders such as: – Type 1 (IgG4-related) autoimmune pancreatitis (AIP) – Salivary gland disease (Mikulicz’s disease)

What does IgG measure?

It is a simple blood test that measures the level of Immunoglobulin G antibodies in the blood. The IgG Serum test is performed to determine the presence of any infection in the body and the level of immunity of our body.

What does IgG indicate?

Immunoglobulin G: IgG is the most common type of antibody in your blood and other body fluids. These antibodies protect you against infection by “remembering” which germs you’ve been exposed to before.

What does IgG stand for?

IgG stands for immunoglobulin G, a type of antibody. Antibodies are proteins made by the immune system to fight viruses, bacteria, and other foreign substances. A CSF IgG index measures the levels of IgG in your cerebrospinal fluid. High levels of IgG can mean you have an autoimmune disorder.