What class of drug is Xgeva?

Xgeva is a monoclonal antibody that works as a RANK ligand (RANKL) inhibitor. This medication is classified as a “bone-modifying agent”.

Is Xgeva a chemotherapy drug?

by Drugs.com Xgeva is not a chemotherapy drug. It is a targeted treatment, called a monoclonal antibody and is classified as a bone-modifying agent. Although it is not a chemotherapy drug it is often given with chemotherapy medicines. Xgeva works as a RANK ligand (RANKL) inhibitor.

Is Xgeva considered a bisphosphonate?

One uncommon but very serious side effect of Xgeva and Zometa (and other bisphosphonates) is jaw bone breakdown, called osteonecrosis of the jaw. Right now, there aren’t good treatment options when osteonecrosis of the jaw happens and the condition can be very disabling.

Is denosumab considered chemotherapy?

Denosumab | Chemotherapy Drug Information | Chemocare.

Is Xgeva a biologic?

THOUSAND OAKS, Calif. , June 19, 2017 /PRNewswire/ — Amgen (NASDAQ: AMGN) today announced that the U.S. Food and Drug Administration ( FDA ) has accepted the XGEVA® (denosumab) supplemental Biologics License Application (sBLA) that seeks to expand the currently approved indication for the prevention of fractures and …

Is denosumab a bisphosphonate?

The difference between denosumab and bisphosphonates for clinical outcomes were change in the skeletal BMD. Denosumab has a greater antiresorptive effect than bisphosphonates. The effects of bisphosphonates for preventing bone loss mainly need bisphosphonates binding to bone mineral.

Is denosumab an immunotherapy?

Immunotherapy with monoclonal antibodies, such as denosumab, pembrolizumab, and nivolumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.

What kind of drug is denosumab?

Denosumab injection (Xgeva) is used Denosumab injection is in a class of medications called RANK ligand inhibitors. It works to prevent bone loss by blocking a certain receptor in the body to decrease bone breakdown. It works to treat GCTB by blocking a certain receptor in the tumor cells which slows the tumor growth.

Is denosumab an immunosuppressant?

Denosumab is an antibody-based medication, but it doesn’t suppress your immune system. This means it doesn’t increase your risk of complications from the coronavirus. This is unlike other antibody-based medications used to treat diseases like rheumatoid arthritis.

Does Xgeva lower immune system?

Denosumab can affect your immune system. You may be more likely to get a serious infection, such as a skin, ear, stomach/gut, or bladder infection.

Which drugs are bisphosphonates?

Osteoporosis Medications (Bisphosphonates)

  • Risedronate (Actonel)
  • Alendronate (Fosamax)
  • Ibandronate (Boniva)
  • Zoledronic Acid (Reclast)
  • Pamidronate (Aredia)
  • Etidronate (Didronel)

Is denosumab a biologic?

Objective: Denosumab is a biologic agent used to treat osteoporosis.