What cells produce CCL25?

(2016) confirmed that CCL25 is mainly expressed in the thymus and intestinal epithelium, and also produced by vascular endothelial cells and other parenchymal cells, which can migrate immature T cells into the thymus to mature and release (Table 1).

What does CCL25 do?

Chemokine ligand 25 (CCL25), expressed by the intestinal epithelial cells, binds to CCR9 on the T lymphocyte and enables homing to the intestinal tissues.

What receptors does CCL25 bind?

Chemokine receptor 9 (CCR9)
Chemokine receptor 9 (CCR9), the main receptor for CCL25, is specifically expressed on a subset of gut-homing T cells expressing integrin α4β7, immunoglobulin A (IgA)-secreting cells from gastrointestinal organs as well as on central nervous system microglia.

What is CCR2 gene?

CCR2 (C-C Motif Chemokine Receptor 2) is a Protein Coding gene. Diseases associated with CCR2 include Idiopathic Anterior Uveitis and Human Immunodeficiency Virus Type 1. Among its related pathways are Akt Signaling and Cytokine Signaling in Immune system.

Where is CCR5 found?

In humans, the CCR5 gene that encodes the CCR5 protein is located on the short (p) arm at position 21 on chromosome 3. Certain populations have inherited the Delta 32 mutation, resulting in the genetic deletion of a portion of the CCR5 gene.

What is Ly6C?

Ly6C is a marker of macrophage subsets and support a model of selective recruitment of Ly6C(high) bone marrow monocytes to the kidney that differentiate into three populations of kidney macrophages, including a profibrotic Ly6C(low) population.

What cell types express CCR2?

CCR2 has been found to be expressed by multiple cell types including monocytes, dendritic cells (DCs), endothelial cells, and cancer cells [51,52,53,54]. CCL2 functions through binding to CCR2, one of 19 members of the human chemokine receptor family [55].

What is CCR7 a marker for?

The chemokine receptor, CCR7, plays a key role in migration of naïve and memory T cells as well as mature dendritic cells (DC) to lymph nodes (LN) through binding to its ligands expressed on high endothelial venules and in T-cell zones within secondary lymphoid organs (20).

Who has CCR5 gene?

All mammal genomes contain a version of CCR5, suggesting that it has an important role in these animals΄ biology. Yet the CCR5-Δ32 mutation is common in some human populations. About 11% of the UK population carries the mutation in at least one copy of the CCR5 gene, and the rate is even higher in parts of Scandinavia.

What is CCR5 used for?

CCR5 is a co-receptor used by HIV in early-stage infection (Scarlatti et al., 1997), and mutation of CCR5 (CCR5Δ32) is known to confer resistance to HIV infection (Huang et al., 1996; Liu et al., 1996; Samson et al., 1996).