What causes multinucleated giant cells?

Multinucleated giant cells (MGCs), which are polykaryons of monocytic origin, are often spatially associated with foreign bodies (ie, introduced exogenous materials) or comprise part of a tissue response to infection. MGCs also appear in autoimmune, neoplastic, and genetic disorders.

What are giant cells granulomas?

Giant cell granuloma is a benign reactive osseous proliferation that shares many features with aneurysmal bone cyst; in many regards, these lesions are indistinguishable. 124. In the head and neck area, the most common sites of occurrence are the maxilla and mandible.

Is giant cell granuloma malignant?

Giant cell granuloma and its related lesions in the jaw are grouped under single umbrella but with varied clinical behavior ranging from simple reactive to neoplasm sometimes even manifesting as aggressive malignant neoplasm.

Are multinucleated cells Bad?

The authors express the necessity to no longer refer to MNGCs as “good” or “bad” cells, but instead point toward the necessity to more specifically characterize them scientifically and appropriately as M1-MNGC and M2-MNGC accordingly.

What virus causes multinucleated giant cells?

Herpes simplex and herpes zoster viruses cause abnormal cell division in epidermal cells, and this creates multinucleated giant cells. These are epidermal cells that are much larger than the normal epidermal cells, and they contain multiple nuclei.

Is giant cell granuloma benign?

Central giant cell granulomas are benign tumours of the mandible, presenting in children and young adults.

Can a giant cell tumor be cancerous?

Most giant cell tumors occur at the ends of the long bones of the arms and legs, near a joint (such as the knee, wrist, hip, or shoulder). Most are benign (not cancer) but some are malignant (cancer).

What do multinucleated giant cells do?

Interestingly, giant cells are most frequently found in the human body as multinucleated osteoclasts located in bone tissues responsible for the resorption of bone, but more recently observed around implanted biomedical devices due to their growing use.

What is the purpose of multinucleated cells?

Multinucleated giant cells are important mediators of tissue remodeling and repair and are also responsible for removal or sequestration of foreign material, intracellular bacteria and non-phagocytosable pathogens, such as parasites and fungi.