What causes Melkersson-Rosenthal syndrome?

The cause of Melkersson-Rosenthal syndrome is unknown, but there may be a familial link although a gene has not yet been identified.

What is Miescher Melkersson-Rosenthal syndrome?

Introduction. Melkersson-Rosenthal syndrome (MRS) is a rare neuro-mucocutaneous disorder with a recurrent and progressive course, characterized by the triad of lip swelling (cheilitis granulomatosa or Miescher cheilitis), fissured tongue (lingua plicata or scrotal tongue) and facial paralysis.

How rare is Melkersson-Rosenthal syndrome?

Melkersson–Rosenthal syndrome is a rare, neuro-mucocutaneous syndrome with an estimated incidence of 0.08% in the general population [14]. Onset of this disease is more frequent in young adults, between the second and the third decades of life [15].

How is Melkersson-Rosenthal syndrome treated?

Treatment for MRS may include corticosteroid injections, nonsteroidal anti-inflammatory agents, antihistamines, and antibiotics. In some patients, MRS may be treated with short courses of immunosuppressants. Surgery and/or radiation are sometimes recommended to reduce abnormally swollen lips.

How do you get rid of orofacial granulomatosis?

What is the treatment of orofacial granulomatosis?

  1. Topical steroids as ointments, creams, mouthwashes or inhalers for mild swelling, oral ulcers, mucosal tags or cobblestoning.
  2. Multiple intralesional cortisone injections for moderate swelling.
  3. Systemic steroids (usually oral prednisone) for moderate-severe swelling.

How long does orofacial granulomatosis last?

In 24 cases, these oral lesions were the first manifestation of systemic sarcoidosis [28,29]. Only some cases of oral sarcoidosis require treatment, because in nearly 60% of patients, the symptoms resolve spontaneously within 2 years.

What triggers orofacial granulomatosis?

Though various aetiological factors like foreign body reactions, infections, Crohn’s disease and Sarcoidosis have been implicated in the disease process. Delayed Hypersensitivity reaction with a predominant Th1-mediated immune response provide further evidence to the etiopathogenesis in Orofacial granulomatosis.

Can orofacial granulomatosis be cured?

As the cause of orofacial granulomatosis has not been determined, there is no curative treatment. Spontaneous remission can occur but is rare. Treatment is offered where there is pain, cosmetic concerns or impaired function.