What causes Ecthyma Gangrenosum?

Ecthyma gangrenosum (Eg) is a rare but typical skin manifestation, most commonly caused by Pseudomonas aeruginosa (Pa), an aerobic Gram-negative opportunistic pathogen that has a high risk of associated mortality in cases where the infection is systemic.

How is SSTI diagnosed?

MRI is the imaging study of choice for diagnosis, though bedside ultrasound may be a useful rapid diagnostic [17, 18]. Source control and empiric antimicrobials directed against MRSA are paramount. Antimicrobials directed against MDR Gram-negative organisms should be added in immunocompromised patients.

How is Ecthyma Gangrenosum treated?

Treatment of EG requires the use of antipseudomonal penicillins, aminoglycosides, fluoroquinolones, third-generation cephalosporins, or aztreonam. While awaiting results, an antipseudomonal penicillin (piperacillin) should be used in conjunction with an aminoglycoside (gentamicin).

What organism is implicated in Ecthyma Gangrenosum?

P. aeruginosa is the most common causative organism of ecthyma gangrenosum. Lesions appear as gangrenous ulcers with erythematous borders located predominantly in the axillary and anogenital areas.

How is Ecthyma Gangrenosum diagnosed?

Ecthyma gangrenosum is suspected when the skin lesions have the characteristic clinical appearance; however, these lesions can easily be missed without a thorough skin examination. Diagnosis generally requires confirmation by additional tests, including blood cultures and skin biopsies.

Is cellulitis a SSTI?

Common Skin and Soft Tissue Infections Common SSTIs include: Abscesses. Cellulitis. Folliculitis.

What is Shanghai fever?

Shanghai fever is a sepsis accompanied by enteric disease caused by P aeruginosa. Hypogammaglobulinaemia is the most common underlying primary immune deficiency in previously healthy children with P aeruginosa sepsis.

What are SSTI infections?

Skin and soft tissue infections (SSTI) are bacterial infections of the skin, muscles, and connective tissue such as ligaments and tendons. Penn Medicine’s SSTI Treatment Clinic provides comprehensive and specialized care, including education, antibiotic treatment and recurrence prevention.