What causes corectopia?

Abstract. BACKGROUND: Corectopia is a defined as an abnormally shaped pupil. It may occur in both congenital and acquired forms. Etiologies include trauma, tumor, pharmacologic, uveitis, Iridocorneal Endothelial Syndromes (ICE) and Reiger’s Syndrome.

What causes Rieger syndrome?

Causes. Axenfeld-Rieger syndrome results from mutations in at least two known genes, PITX2 and FOXC1. PITX2 gene mutations cause type 1, and FOXC1 gene mutations cause type 3. The gene associated with type 2 is likely located on chromosome 13, but it has not been identified.

What is Rieger Anomaly?

Disease definition. Rieger’s anomaly is a congenital ocular defect caused by anterior segment dysgenesis and is characterized by severe anterior chamber deformity with prominent strands and marked atrophy of the iris stroma, with hole or pseudo-hole formation and corectopia.

Is corectopia treatable?

Corectopia is the displacement of the eye’s pupil from its normal, central position. It may be associated with high myopia or ectopia lentis, among other conditions. Medical or surgical intervention may be indicated for the treatment of corectopia in some cases.

How do people with corectopia see?

Patients frequently present with decreased vision and pain. Iris abnormalities are not typical. Corneal edema and blurred vision are often worse upon awakening in the early stage of the disease. Later in the disease, the corneal edema, decreased vision, and pain may persist throughout the day.

What is Macrocornea?

Megalocornea, also known as anterior megalophthalmos, X-linked megalocornea, and macrocornea, is a rare bilateral nonprogressive congenital defect that is characterized by an increased corneal diameter greater than 12.5 to 13 mm at birth and a deep anterior chamber with normal intraocular pressures.

What is Embryotoxon?

Embryotoxon is a congenital defect in which opacity appears at the periphery of the innermost surface of the cornea. Of 723 patients evaluated initially, 49 were identified with posterior embryotoxon, an overall prevalence rate of 6.8%. In this group, patients ranged in age from 18 months to 95 years old.

Is corectopia inherited?

The ocular features may resemble Rieger or Axenfeld anomaly but these are inherited in autosomal dominant patterns and the skeletal features are dissimilar.

What is Megalophthalmos?

A congenital condition in which the eye is abnormally large, particularly the structures of the anterior segment. The condition is associated with megalocornea, Marfan’s syndrome and Apert’s syndrome.

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