What cancers are associated with CHEK2?

Individuals with CHEK2 gene mutations have an increased risk for cancers of the breast, colon, prostate, and possibly thyroid and kidney.

Is CHEK2 hereditary?

Everyone has two copies of the CHEK2 gene, which we randomly inherit from each of our parents. Mutations in one copy of the CHEK2 gene can increase the chance for you to develop certain types of cancer in your lifetime.

Is CHEK2 the same as BRCA?

A breast cancer survivor with a BRCA1 or BRCA2 mutation has a high risk of ovarian cancer. In contrast, a woman with a CHEK2 mutation and no family history of ovarian cancer would not be presumed to have an elevated risk of ovarian cancer.

Are most cancers genetic?

Inherited genetic mutations play a major role in about 5 to 10 percent of all cancers. Researchers have associated mutations in specific genes with more than 50 hereditary cancer syndromes, which are disorders that may predispose individuals to developing certain cancers.

Is CHEK2 worse than BRCA?

CHEK2 serves the body as a tumor suppressor, but when it’s mutated, it can be linked to numerous cancers. It is considered a more moderate-risk gene mutation. Today, most people have likely heard of BRCA1, BRCA2 and PALB2 for good reason — they confer a much higher risk of developing breast cancer.

What do I do if I have CHEK2?

The knowledge that you have a CHEK2 mutation can help you and your doctor plan prevention strategies. You may also be able to identify at-risk family members who could have the mutation, too. If your test comes back positive, you might benefit from earlier cancer screenings.

Which is worse BRCA1 or CHEK2?

Is CHEK2 mutation rare?

Although CHEK2 mutations are rare, the risk of developing breast cancer is higher in carriers of truncating mutations. This risk is correlated with family history and increases when the carriers have first- and second-degree relatives who are affected.

Does your bloodline come from your father?

Well, your blood is definitely all your own–your body produced it. But because of how the genetics of blood type works, it could seem like you have your mom’s blood type, your dad’s blood type, or a mix of the two. For every gene, you get two copies — one from your mom and one from your dad.