What are the symptoms of FMF?

Signs and symptoms of FMF attacks vary, but can include:

  • Fever.
  • Abdominal pain.
  • Chest pain, which can make it hard to breathe deeply.
  • Painful, swollen joints, usually in the knees, ankles and hips.
  • A red rash on your legs, especially below your knees.
  • Muscle aches.
  • A swollen, tender scrotum.

Can a carrier of FMF have symptoms?

Approximately 90 percent of individuals with FMF experience abdominal symptoms that can range from mild bloating to inflammation of the lining of the abdomen (peritonitis).

What causes Polyserositis?

There aetiology of polyserositis is wide, with more common causes encompassing autoimmune disorders (systemic lupus erythematosus and rheumatoid arthritis),2 3 infection (Mycoplasma pneumoniae, Legionella pneumophila, tuberculosis, coxsackievirus, Epstein-Barr virus, cytomegalovirus and Q fever),1 autoinflammatory …

How is FMF diagnosed?

Genetic testing. Genetic testing may determine if your MEFV gene contains a gene change that is associated with FMF . Genetic tests aren’t advanced enough to test for every gene change that’s linked to FMF , so there is a possibility of false-negative results.

Is FMF autoimmune disease?

As opposed to an autoimmune disease in which the immune system attacks its own cells, FMF is an autoinflammatory disease in which the innate immune system (the body’s first-line defense) simply doesn’t work as it is should.

What type of doctor treats familial Mediterranean fever?

If you have signs and symptoms of familial Mediterranean fever, you may begin by seeing your family health care provider. Your health care provider may refer you to a specialist in inflammatory diseases (rheumatologist).

How do you treat Polyserositis?

A number of drugs, including amiodarone, bleomycin, dantrolene, hydralazine, isoniazid, methotrexate, methysergide, mitomycin, procainamide, and procarbazine, can cause pleural effusions. Treatment consists of discontinuing the offending agent, although treatment with oral corticosteroids may be needed (Chapter 262).

What is TB Polyserositis?

Polyserositis describes contemporaneous inflammation of multiple serous membranes accompanied by effusions in serous cavities. It has been associated with different aetiologies, including autoimmune diseases, endocrine diseases, neoplasia, drug-associated cases, and infectious diseases, such as tuberculosis.