What are the side effects of danazol?

Danazol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • acne.
  • decrease in breast size.
  • weight gain.
  • oily skin or hair.
  • flushing.
  • sweating.
  • vaginal dryness, burning, itching, or bleeding.
  • nervousness.

How does danazol treat hereditary angioedema?

In hereditary angioedema, a rare genetic disorder marked by insufficient blood levels of the C1 esterase inhibitor (C1INH) protein and C4 protein, Danocrine helps to prevent spontaneous edema attacks by increasing C1INH and C4 levels in the blood.

Is danazol a black box warning?

Danazol is a estrogen antagonist, endocrine metabolic agent that is FDA approved for the treatment of endometriosis, fibrocystic breast disease, hereditary angioedema. There is a Black Box Warning for this drug as shown here. Common adverse reactions include acne, weight gain.

Why is danazol discontinued?

Mylan have discontinued their brand of danazol. Danazol was delisted from the Schedule on 1 April 2021. Mylan discontinued this product because of global supply constraints and viability of this product.

What is indication of danazol?

Danazol capsules are indicated for the prevention of attacks of angioedema of all types (cutaneous, abdominal, laryngeal) in males and females.

What is danazol indication?

Is danazol an aromatase inhibitor?

Conclusion(s): Danazol competitively inhibited aromatase activity in endometriosis-derived stromal cells without affecting either the mRNA or protein levels of aromatase. These results indicate the efficacy of local application of danazol to endometriotic lesions.

How long can you take danazol for?

Adults—At first, 800 milligrams (mg) per day, divided in two doses, for at least 3 to 6 months and up to 9 months. Your doctor may adjust your dose as needed and tolerated.

Can danazol be taken long term?

We conclude that, despite a relatively high incidence of adverse reactions, danazol has proven to be remarkably safe over the long-term in this group of patients.

What is the rationale for using danazol?

Danazol acts by inhibiting the midcycle follicle-stimulating hormone (FSH) and luteinizing hormone (LH) surges and preventing steroidogenesis in the corpus luteum. It is the most extensively studied agent for endometriosis.