What are the four types of osteogenesis imperfecta?

What are the four types of osteogenesis imperfecta?

What are the types of osteogenesis imperfecta?

• Type I: This is the mildest and most common form of OI. Type I leads to broken bones (bone fractures) or muscle weakness.
• Type II: Babies born with Type II often can’t breathe and die young.
• Type III: Babies often have broken bones at birth.
• Type IV: Bones may break easily.

What is osteogenesis imperfecta Type 3?

Type III. Most severe type in babies who don’t die as newborns. At birth, a baby may have slightly shorter arms and legs than normal and arm, leg, and rib fractures. A baby may also have a larger than normal head, a triangle-shaped face, a deformed chest and spine, and breathing and swallowing problems.

What is osteogenesis imperfecta Type 2?

A lethal type of osteogenesis imperfecta (OI) characterized by increased bone fragility, low bone mass and susceptibility to bone fractures and presenting with multiple rib and long bone fractures at birth, marked deformities, broad long bones, low density skull on X-ray, and dark sclera.

What is the most common type of osteogenesis imperfecta?

Osteogenesis type I is the most common and usually the mildest form of OI. In most people, it is characterized by multiple bone fractures, usually occurring during childhood through puberty.

What are the 2 types of osteogenesis?

Type I (also known as classic non-deforming osteogenesis imperfecta with blue sclerae) is the mildest form of osteogenesis imperfecta. Type II (also known as perinatally lethal osteogenesis imperfecta) is the most severe.

What is OI type 1?

Summary. Osteogenesis imperfecta (OI) is a group of genetic disorders that mainly affect the bones. Osteogenesis imperfecta type 1 is the mildest form of OI and is characterized by bone fractures during childhood and adolescence that often result from minor trauma. Fractures occur less frequently in adulthood.

Is Type 3 OI dominant or recessive?

OI type III is caused by changes in the COL1A1 or COL1A2 genes and is inherited in an autosomal dominant manner.

Can a baby survive osteogenesis imperfecta Type 2?

A baby with type II OI usually dies within weeks of birth. Type III. Most severe type in babies who don’t die as newborns. At birth, a baby may have slightly shorter arms and legs than normal and arm, leg, and rib fractures.

Is osteogenesis imperfecta Type 2 fatal?

OI type II is the most severe form. It is a lethal form with collagen abnormalities resulting in dwarfism, bone fragility and deformity with in utero or perinatal death [2]. There are diagnosis difficulties between OI and other skeletal dysplasia.

Does osteogenesis imperfecta affect the brain?

Abstract. Osteogenesis imperfecta (OI) is a rare genetic disorder characterized by disruption of normal collagen formation resulting in varying degrees of skeletal vulnerability, ligamentous laxity, and scleral discoloration. Children with OI may suffer from complex neurosurgical problems affecting the brain and spine.

Is osteogenesis imperfecta fatal?

Type 2 OI. Type 2 OI is often fatal. A child with type 2 OI may die in the womb or shortly after birth from respiratory problems.