What are the family of transcription factors?

How Transcription Factors Are Identified The major TF families in eukaryotes, such as C2H2-zinc finger (ZF), Homeodomain, basic helix-loop-helix (bHLH), basic leucine zipper (bZIP), and nuclear hormone receptor (NHR), were initially described in the 1980s (reviewed in Johnson and McKnight [1989]).

What are WRKY genes?

WRKY gene involved in plant defense, hormone signaling, and secondary metabolism are regulated by phosphorylation via mitogen-activated protein kinase (MAPK) cascades. Additionally, a MAPK can phosphorylate a VQ protein, freeing the WRKY transcription factor for target gene activation.

Is ap2 a transcription factor?

Function. Transcription factor AP-2 alpha is a 52-kD sequence-specific DNA-binding protein that enhances transcription of specific genes by binding to a GC-rich DNA sequence first identified in the cis-regulatory region of SV40 virus DNA and in cis-regulatory regions of a variety of cellular genes.

How many general transcription factors are there?

Five general transcription factors are required for initiation of transcription by RNA polymerase II in reconstituted in vitro systems (Figure 6.12). The promoters of many genes transcribed by polymerase II contain a sequence similar to TATAA 25 to 30 nucleotides upstream of the transcription start site.

How do I target my transcription factor?

Here, we discuss various ways to target transcription factors in cancer models: by modulating their expression or degradation, by blocking protein/protein interactions, by targeting the transcription factor itself to prevent its DNA binding either through a binding pocket or at the DNA-interacting site, some of these …

What is AP gene?

Activator protein 1 (AP-1) is a transcription factor that regulates gene expression in response to a variety of stimuli, including cytokines, growth factors, stress, and bacterial and viral infections.

What are the 5 general transcription factors in eukaryotes?

The holoenzyme consists of a preformed complex of RNA polymerase II, the general transcription factors TFIIB, TFIIE, TFIIF, and TFIIH, and several other proteins that activate transcription.