What are the extrahepatic manifestations of chronic HCV infection?

These autoantibodies are not associated with manifestations of connective-tissue disease. Other, rare HCV-related extrahepatic manifestations include autoimmune cytopenia (hemolytic anemia and thrombocytopenia), skin manifestations (lichen planus and porphyria cutanea tarda), and hypothyroidism.

Which is an extrahepatic complication of HCV infection?

Complications of cryoglobulinemia include rash, vasculitis, and glomerulonephritis. Other extrahepatic complications of HCV infection include focal lymphocytic sialadenitis, autoimmune thyroiditis, porphyria cutanea tarda, lichen planus, and Mooren corneal ulcer.

Which condition is the most common extrahepatic manifestation in patients with HCV infection?

The most common conditions are purpura and Raynaud’s phenomenon. 98 Palpable purpura occurs in up to 90% of cases. It is caused by extravasation of red blood cells into the dermis and appears on the skin of lower extremities.

What are the clinical manifestations of chronic hepatitis?

Most people have no symptoms, but some have vague symptoms, such as a general feeling of illness, poor appetite, and fatigue. Chronic hepatitis can progress to cirrhosis and ultimately liver cancer and/or liver failure.

Does HCV cause Cryoglobulinemia?

Cryoglobulinemia and Hepatitis C The condition most commonly linked with hep C is cryoglobulinemia. This condition is due to the presence of abnormal antibodies (called cryoglobulins) that come from hepatitis C virus stimulation of lymphocytes (white blood cells).

What are extrahepatic diseases?

Extrahepatic means “outside the liver,” so this type of cancer refers to cancer that begins in the bile duct outside your liver.

What are some of the extra hepatic complications of acute hepatitis?

Serum Sickness—Like Syndrome. A transient serum sickness—like syndrome develops in 10—20% of patients with acute HBV infection.

  • Glomerulonephritis. The incidence of HBV glomerulonephritis ranges from 0.1% to 25%.
  • Polyarteritis Nodosa.
  • Dermatologic Conditions.
  • Cryoglobulinemia.
  • Guillain-Barré Syndrome.

    • What is cryoglobulinemia vasculitis?

    Cryoglobulinemic vasculitis occurs when the body makes a mix of abnormal immune system proteins called cryoglobulins. At temperatures less than 98.6 degrees Fahrenheit (normal body temperature), cryoglobulins become solid or gel-like and can block blood vessels. This causes a variety of health problems.

    What do chronic hepatitis infections result in?

    Having a chronic HBV infection can lead to serious complications, such as: Scarring of the liver (cirrhosis). The inflammation associated with a hepatitis B infection can lead to extensive liver scarring (cirrhosis), which may impair the liver’s ability to function. Liver cancer.

    What are types of chronic hepatitis?

    Chronic hepatitis is hepatitis that lasts > 6 months. Common causes include hepatitis B and C viruses, nonalcoholic steatohepatitis (NASH), alcohol-related liver disease, and autoimmune liver disease (autoimmune hepatitis).

    What are extrahepatic organs?

    Listen to pronunciation. (EK-struh-heh-PA-tik) Located or occurring outside the liver.