What are the contraindication of carbamazepine?

Carbamazepine is contraindicated in patients with bone marrow depression and hypersensitivity to this drug or tricyclic compounds such as amitriptyline. [20] Before administration, monoamine oxidase inhibitors should be discontinued for a minimum of 14 days.

Which patient is contraindicated with Tegretol?

Contraindications. Tegretol should not be used in patients with a history of previous bone marrow depression, hypersensitivity to the drug, or known sensitivity to any of the tricyclic compounds, such as amitriptyline, desipramine, imipramine, protriptyline, nortriptyline, etc.

What medicines interact with carbamazepine?

Inhibition of carbamazepine metabolism and elevation of plasma carbamazepine to potentially toxic concentrations can be caused by stiripentol, remacemide, acetazolamide, macrolide antibiotics, isoniazid, metronidazole, certain antidepressants, verapamil, diltiazem, cimetidine, danazol and (dextropropoxyphene) …

What is side effect of carbamazepine?

Nausea, vomiting, dizziness, drowsiness, constipation, dry mouth, or unsteadiness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

What is carbamazepine side effects?

Nausea, vomiting, dizziness, drowsiness, constipation, dry mouth, or unsteadiness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly….Common side effects may include:

  • dizziness, loss of coordination, problems with walking;
  • nausea, vomiting; or.
  • drowsiness.

What does Tegretol interact with?

CYP3A4 inducers can increase the rate of Tegretol metabolism. Drugs that have been shown, or that would be expected, to decrease plasma carbamazepine levels include cisplatin, doxorubicin HCl, felbamate, fosphenytoin, rifampin, phenobarbital, phenytoin, primidone, methsuximide, theophylline, aminophylline.

What are the long term side effects of carbamazepine?

To date, there are no known problems associated with long term use of carbamazepine. It is a safe and effective medication when used as directed.

Can carbamazepine cause high blood pressure?

Although rare, a variety of cardiovascular effects including hypertension have been reported with carbamazepine. Numerous mecha- nisms may be responsible; however, shared pharmacologic properties with the tricyclic antidepressants are suspect. Hypertension is a rare side effect of carbamazepine.

Why is carbamazepine contraindicated in patients with antidepressant hypersensitivity?

Carbamazepine is structurally related to tricyclic antidepressants and is contraindicated in patients with a tricyclic antidepressant hypersensitivity.

Does carbamazepine affect co-medication levels?

Decreased Levels of Concomitant Medications. Carbamazepine is a potent inducer of hepatic 3A4 and is also known to be an inducer of CYP1A2, 2B6, 2C9/19 and may therefore reduce plasma concentrations of co-medications mainly metabolized by CYP 1A2, 2B6, 2C9/19 and 3A4, through induction of their metabolism.

What should I avoid while taking carbamazepine?

• Do not drive, operate heavy machinery, or do other dangerous activities until you know how Carbamazepine affects you. Carbamazepine may slow your thinking and motor skills. What are the possible side effects of Carbamazepine?

Is isavuconazonium contraindicated with carbamazepine?

Isavuconazonium: (Contraindicated) Concomitant use of isavuconazonium with carbamazepine is contraindicated due to the potential for decreased isavuconazole serum concentrations and treatment failure.