What are the classification of antifungal drugs?

Antifungals can be grouped into three classes based on their site of action: azoles, which inhibit the synthesis of ergosterol (the main fungal sterol); polyenes, which interact with fungal membrane sterols physicochemically; and 5-fluorocytosine, which inhibits macromolecular synthesis.

What are antifungal drugs give the classification with example?

There are two subgroups of azole antifungals: imidazoles and triazoles. Examples of imidazole antifungals and the conditions they treat are: Ketoconazole: infections of the skin and hair, Candida infections of the skin and mucous membranes, blastomycosis, histoplasmosis. Clotrimazole: skin and mucous membrane …

What is antifungal pharmacology?

An antifungal medication, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete’s foot, ringworm, candidiasis (thrush), serious systemic infections such as cryptococcal meningitis, and others.

What are the two classes of polyene antifungal?

The polyene antifungals include nystatin and amphotericin B. They have the advantage of being fungicidal by binding to ergosterol in the fungal cell wall, creating pores in the membrane.

How many antifungal drugs are there?

In the United States, only 10 antifungal drugs are currently approved by the Food and Drug Administration (FDA) for the therapy of systemic fungal infections. As shown in table 1, these drugs belong to 3 principal classes: polyenes, pyrimidines, and azoles.

What class of drug is terbinafine?

Descriptions. Terbinafine belongs to the group of medicines called antifungals.

What are azole drugs?

Azoles are synthetic antifungals with broad-spectrum fungistatic activity against yeasts and fungi, including candidal species. By blocking fungal cytochrome P450-dependent enzymes, azoles disrupt the synthesis of ergosterol, which is the principal sterol in fungal cell membranes.

Who invented antifungal drugs?

Elizabeth Lee Hazen and Rachel Brown created the first useful antifungal antibiotic, nystatin, through a long-distance scientific collaboration. As researchers for the New York State Department of Health, Hazen in New York City and Brown in Albany shared tests and samples through the U.S. mail.

What are antifungal compounds?

Definition. An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Is griseofulvin an antifungal?

Griseofulvin belongs to the group of medicines called antifungals. It is used to treat fungus infections of the body, feet, groin and thighs, scalp, skin, fingernails, and toenails.

What is another name for terbinafine?

Lamisil (terbinafine hydrochloride) Tablets are indicated for the treatment of onychomycosis of the toenail or fingernail due to dermatophytes (tinea unguium).