What are symptoms of cerebellar hypoplasia?

What are symptoms of cerebellar hypoplasia?

In an infant or young child, symptoms of a disorder that features cerebellar hypoplasia might include floppy muscle tone, developmental or speech delay, problems with walking and balance, seizures, intellectual disability, and involuntary side to side movements of the eyes.

What is vermian hypoplasia?

Isolated inferior vermian hypoplasia (IIVH), also referred as part of Dandy-Walker variant (DWV), is a congenital malformation characterized by partial absence of the inferior portion of the cerebellar vermis.

What does the cerebellar vermis do?

midline of the cerebellum; it separates the cerebellum into two cerebellar hemispheres. The vermis is thought to be associated with the ability to maintain upright posture.

What causes cerebellar hypoplasia in humans?

Cerebellar hypoplasia may result from prenatal disruptions due to hemorrhage, ischemia, and infections such as cytomegalovirus or exposure to drugs (Poretti et al., 2009b). Clinical features and prognosis are heterogeneous and reflect the specific cause.

What causes Vermian hypoplasia?

Cerebellar vermis hypoplasia. Cerebellar vermis hypoplasia is associated with a normal position of the cerebellar vermis relative to the brainstem or minimal upward rotation due to a mildly enlarged fourth ventricle, without elevation of the tentorium.

Is cerebellar hypoplasia a disability?

Cerebellar hypoplasia is a developmental anomaly that appears to be either etiologically related to, or a marker for, developmental disability, thus confirming the intact cerebellum’s integral role in normal psychomotor development.

What is a vermian?

1 : of, relating to, or resembling worms. 2 : of or relating to the vermis of the cerebellum.

Can cerebellar hypoplasia be cured?

There is no cure or treatment for cerebellar hypoplasia, but as noted before, the symptoms will not worsen. With some help, many kittens will learn to live with their disabilities.

When does the cerebellar vermis develop?

By the second trimester of pregnancy, the fissures of the cerebellar cortex have appeared. The cerebellar hemisphere and the vermis, which form the roof of the fourth ventricle, grow rapidly (Kapur et al. 2009), and during the second trimester the tentorium of the cerebellum is being shaped.

Is cerebellar hypoplasia fatal?

The characteristic symptoms of this disorder lead to its common name of “wobbly cat syndrome.” Feline cerebellar hypoplasia is not typically a life-threatening condition, but it can have a negative impact on the cat’s quality of life depending on the severity.

What is vermian agenesis?

Vermian agenesis means either complete or partial absence of the vermis. In partial vermian agenesis, part of the vermis is absent and the remaining part is anatomically of normal volume. Due to the craniocaudal development of the vermis, partial agenesis involves its inferior part.

What is isolated cerebellar vermis hypoplasia?

Isolated cerebellar vermis hypoplasia (Concept Id: C4707794) A rare non-syndromic cerebellar malformation characterized by an underdeveloped cerebellar vermis.

What is the history of cerebellar hypoplasia?

Cerebellar hypoplasia. It consists of a heterogeneous group of disorder of cerebellar maldevelopment presenting as early onset non progressive ataxia, hypotonia, and motor learning disability. Various causes has been incriminated like hereditary, metabolic, toxic and viral agents. First reported by Crouzon in 1929.

Is cerebellar hypoplasia associated with hydrocephalus?

Cerebellar hypoplasia can sometimes present alongside hypoplasia of the corpus callosum or pons. It can also be associated with hydrocephalus or an enlarged fourth ventricle; this is called Dandy–Walker malformation.

What are the signs and symptoms of cerebellar hypoplasia?

Cerebellar hypoplasia can sometimes present alongside hypoplasia of the corpus callosum or pons. It can also be associated with hydrocephalus or an enlarged fourth ventricle; this is called Dandy–Walker malformation. Non-progressive early onset ataxia and poor motor learning are the most common presentation.