What are some effects and side effects of acetylcholinesterase inhibitors in humans?
What are some effects and side effects of acetylcholinesterase inhibitors in humans?
Some common side effects or adverse events of cholinesterase inhibitors are:
- Nausea.
- Vomiting.
- Diarrhea.
- Muscle cramps.
- Weight loss.
- Headache.
- Insomnia.
- Abnormal dreams.
Why does Anticholinesterase cause side effects?
Anticholinesterases (anti-ChEs) are toxic to humans principally because they interfere with molecular and cellular mechanisms required for the normal functioning of the central nervous system (CNS) and peripheral nervous system (PNS).
What is anticholinesterase poisoning?
Anticholinesterase poisoning was defined as the presence of nicotinic and/or muscarinic clinical features in combination with either (a) a history of exposure to an organophosphate or carbamate insecticide, or (b) a decreased level of serum pseudocholinesterase.
What are the side effects of Alzheimer’s medication?
Side effects may cause sleepiness, dizziness, mood swings, and confusion. Antipsychotics are drugs used to treat paranoia, hallucinations, agitation, and aggression. Side effects of using these drugs can be serious, including increased risk of death in some older people with dementia.
What happens to acetylcholine in Alzheimer’s?
In Alzheimer’s disease some of the nerve cells that use acetylcholine are also lost. Because of these changes in the brain, symptoms of Alzheimer’s disease get worse over time. Donepezil, rivastigmine and galantamine all prevent an enzyme called acetylcholinesterase from breaking down acetylcholine.
Which is a muscarinic effect of an anticholinesterase overdose?
Muscarinic signs (SLUDGE) salivation, lacrimation, urination, diaphoresis, gastrointestinal upset, emesis and progressing to bronchospasm, bronchorrhea, blurred vision, bradycardia or tachycardia, hypotension, confusion, and shock.