What are Plasmacytes?

(PLAZ-muh-site) A type of immune cell that makes large amounts of a specific antibody. Plasmacytes develop from B cells that have been activated. A plasmacyte is a type of white blood cell. Also called plasma cell.

What are Plasmablasts?

In immunology, a “plasmablast” refers to a short-lived differentiation stage between a post germinal centre B-cell and a mature plasma cell. Plasmablasts retain a proliferative capability together with an almost fully mature plasma cell phenotype [1].

Can you culture B cells?

Fresh or frozen human primary B cells can also be sourced directly from STEMCELL and immediately cultured in ImmunoCult™. (B) Expand and harvest mature B cells by culturing the isolated B cells with ImmunoCult™ Human B Cell Expansion Kit for 12 – 15 days.

What are B cell subsets?

Naïve B cells are generally divided into three subsets, B-1 B cells, follicular B cells, and marginal zone (MZ) B cells. B-1 B cells are typically subdivided into B-1a and B-1b B cells.

What is a necron Plasmacyte?

Plasmacytes are a kind of Necron construct. Their primary purpose is to isolate and siphon corrupted engrams from slumbering Necrons. While they themselves are fairly harmless machines, Plasmacytes can use their Monomolecular Proboscis to inject an infectious, sentient energy into members of the Destroyer Cult.

What is bone marrow Plasmacytosis?

IN RECENT YEARS an increased percentage of plasma cells in the bone marrow and other tissues of the body has been noted in many diseases other than the primary malignant plasmacytic diseases (multiple myeloma, diffuse plasma cell myelosis, and plasma cell leukemia). This condition has been termed plasmacytosis.

How Plasmablasts are formed?

If a naive B cell is activated by antigen in a secondary lymph node, it will differentiate into antibody-secreting cells called plasmablasts. Some of these plasmablasts will mature in the secondary lymphoid organ itself into plasma cells with short life spans that will secrete antibodies locally.

Where are Plasmablasts found?

Plasmablasts are generated in secondary lymphoid organs. They become migratory, leave the spleen/lymph nodes guided via S1P1, and travel via the blood to the bone marrow parenchyma.

How B cells are extracted?

Primary immune cells were obtained from spleens by mechanical disruption followed by brief settlement under gravity to remove tissue fragments. B cells were obtained by negative selection using Pan B Cell Isolation Kit II (Miltenyi, cat 130-104-443).

What does CD mean in CD4?

cluster of differentiation
CD (cluster of differentiation) antigens are cell-surface molecules expressed on leukocytes and other cells relevant for the immune system.