What are fluoroquinolone antibiotics used to treat?

The fluoroquinolones are indicated for treatment of several bacterial infections, including bacterial bronchitis, pneumonia, sinusitis, urinary tract infections, septicemia and intraabdominal infections, joint and bone infections, soft tissue and skin infections, typhoid fever, anthrax, bacterial gastroenteritis.

When should fluoroquinolones be used?

Fluoroquinolones: Cipro, Levaquin & Avelox. Fluoroquinolones such as Cipro, Levaquin and Avelox are antibiotics approved to treat or prevent serious bacterial infections, including skin, bone and joint, lower respiratory tract and urinary tract infections. They work by killing or stopping the growth of certain bacteria …

Why do doctors prescribe fluoroquinolones?

When bacterial infections are hard to prevent or treat, doctors often turn to a class of antibiotics called fluoroquinolones to stop their spread. These medications are known as ciprofloxacin, moxifloxacin, gemifloxacin, levofloxacin, and ofloxacin.

What is the primary target of fluoroquinolone antibiotics?

Mechanisms of fluoroquinolone action Fluoroquinolones target DNA gyrase and topoisomerase IV with varying efficiency in different bacteria and inhibit their control of supercoiling within the cell, resulting in impaired DNA replication (at lower concentrations) and cell death (at lethal concentrations) [10,15].

Is azithromycin A fluoroquinolones?

Azithromycin is a semisynthetic macrolide antibiotic, whereas levofloxacin is a fluoroquinolones antibiotic. Since its release in early 1990s, azithromycin has become the most commonly prescribed macrolide antibiotics in the US.

Is amoxicillin a fluoroquinolone?

Amoxicillin and Levaquin (levofloxacin) are both antibiotics used to treat a variety bacterial infections. Levaquin belongs to the fluoroquinolone class of antibiotics, while amoxicillin is a penicillin type of antibiotic.

What bacteria is resistant to fluoroquinolones?

Gram positive bacteria are inherently less susceptible to fluoroquinolones than many Gram negative bacteria, so bacteria such as Streptococcus pneumoniae typically require only one, sometimes two, mutations in the genes encoding the target proteins to become clinically resistant.

What are the adverse effects of fluoroquinolones?

The serious side effects include tendonitis, tendon rupture, arthralgia, pain in extremities, gait disturbance, neuropathies associated with paraesthesia, depression, fatigue, memory impairment, sleep disorders, and impaired hearing, vision, taste and smell.

What is levofloxacin 500 mg used for?

Levofloxacin is used to treat bacterial infections in many different parts of the body. It is also used to treat anthrax infection after inhalational exposure. Levofloxacin is also used to treat and prevent plague (including pneumonic and septicemic plague).

Which is stronger azithromycin or levofloxacin?

The bacterial eradication rates of respiratory pathogens were 96% for azithromycin and 85% for levofloxacin.