Is paclitaxel the same as tamoxifen?

Paclitaxel is a natural product-based agent and is thus subject to the problem of multidrug resistance (MDR). Tamoxifen is an agent that can abrogate MDR and potentially enhance the effect of paclitaxel. A Phase II trial of the combination was undertaken with previously treated patients.

Which medication should be given before administering paclitaxel?

Such premedication may consist of dexamethasone 20 mg PO administered approximately 12 and 6 hours before paclitaxel injection, diphenhydramine (or its equivalent) 50 mg IV 30 to 60 minutes prior to paclitaxel injection, and cimetidine (300 mg) or ranitidine (50 mg) IV 30 to 60 minutes before paclitaxel injection.

Is Taxol given before Herceptin?

Detailed Description: Patients will receive Herceptin intravenously once weekly for 12 weeks, and Taxol intravenously every 3 weeks (week 1, week 4, week 7 and week 10). After 12 weeks of treatment, breast surgery will be performed (either a lumpectomy or a mastectomy).

Why carboplatin is given after paclitaxel?

Official Answer. Taxol (paclitaxel, Paxel) must be given before carboplatin because if carboplatin is given before Taxol, it stops Taxol from having an effect on cancer cells.

How successful is paclitaxel?

The estimated 5-year overall survival rates were 86.5% for the group receiving paclitaxel every 3 weeks, 89.7% for the group receiving weekly paclitaxel, 87.3% for the group receiving docetaxel every 3 weeks, and 86.2% for the group receiving weekly docetaxel.

Is Taxol and paclitaxel the same?

Paclitaxel is a chemotherapy drug. It is a treatment for many different types of cancer. It is also called Taxol.

What are the Premeds for Taxol?

The paclitaxel premedication regimen consists of an antihistamine (eg, diphenhydramine), a corticosteroid (eg, dexamethasone), and an H2 receptor antagonist (eg, famotidine). Early studies of paclitaxel demonstrated high rates of hypersensitivity reactions.

What is given with paclitaxel?

First-line chemotherapy of breast carcinoma: When used in combination with doxorubicin (50 mg/m2), paclitaxel should be administered 24 hours after doxorubicin. The recommended dose of paclitaxel is 220 mg/m2 administered intravenously over a period of 3 hours, with a 3-week interval between courses (see 4.5 and 5.1).

Does Taxol always cause hair loss?

The drugs paclitaxel (“Taxol”) and docetaxel (“Taxotere “), nearly always cause complete alopecia when given in a third weekly schedule, but hair loss is less frequent when the drugs are given in a weekly schedule.

How do you feel after paclitaxel?

You might have a mild allergic reaction to paclitaxel during or shortly after treatment. This can cause symptoms such as itching, rash or red face. Rarely you can get a severe allergic reaction. Symptoms include breathlessness, swelling of your face and lips, and dizziness.

Does paclitaxel cause hair loss?

Hair loss. Paclitaxel causes hair loss. Most people will lose all their hair, including eyebrows, eyelashes and body hair. You may begin to lose your hair about two weeks after the first treatment, but it can happen earlier.