Is norcocaine active?
Is norcocaine active?
Norcocaine (NC), through an oxidative metabolism, is one of the few metabolites that are pharmacologically active. NC undergoes further metabolism to norcocaine nitroxide, which is hepatotoxic in animals [14–20].
What is Norcocaine used for?
The local anesthetic potential of norcocaine has been shown to be higher than that of cocaine, however cocaine continues to be more widely used. Norcocaine used for research purposes is typically synthesized from cocaine….Norcocaine.
| Clinical data | |
|---|---|
| CAS Number | 18717-72-1 |
| PubChem CID | 644007 |
| ChemSpider | 559083 |
| UNII | 3SL7BR2M1E |
What is ecgonine used for?
Ecgonine methyl ester is the O-debenzoyl analogue of cocaine. It has a role as a central nervous system depressant, a peripheral nervous system drug, an analgesic, a metabolite, an opioid analgesic and a mouse metabolite.
What are metabolites?
Listen to pronunciation. (meh-TA-boh-lite) A substance made or used when the body breaks down food, drugs or chemicals, or its own tissue (for example, fat or muscle tissue). This process, called metabolism, makes energy and the materials needed for growth, reproduction, and maintaining health.
What can make you test positive for benzoylecgonine?
There is an isolated report of antibody-mediated interference in EMIT for benzoylecgonine. However, true positive test results may occur due to drinking herbal tea containing cocaine or application of cocaine as an anesthetic agent during ENT surgery.
Is ecgonine methyl ester an active metabolite?
Recently, ecgonine methyl ester (methylecgonine) has been shown to be major urinary metabolite of cocaine in man after oral administration.
What is benzoylecgonine and ecgonine methyl ester?
Benzoylecgonine (BE) and ecgonine methyl ester (EME) are supposed to be the major hydrolysis products in human plasma. BE is formed by chemical hydrolysis of the methyl ester group, and small amounts of EME are formed enzymati- cally by hydrolysis of the benzoyl ester (2,4).
What are the two types of metabolites?
Plant metabolites are of two types:
- Primary Metabolites.
- Secondary Metabolites.
What can benzoylecgonine be found in?
Benzoylecgonine is the major metabolite of cocaine. It is formed by hydrolysis of cocaine in the liver, catalysed by carboxylesterases. It is excreted in the urine of cocaine users after processing in the liver.
