Is dexmedetomidine safer than medetomidine?

Conclusions and clinical relevance: Dexmedetomidine is at least as safe and effective as medetomidine for use as a premedicant in dogs undergoing propofol-isoflurane anesthesia.

Which reversal agent is best used with medetomidine?

Atipamezole is an α2-adrenoceptor antagonist that rapidly reverses the effects of medetomidine on central and peripheral receptors to restore cardiovascular, respiratory, and gastrointestinal function, thereby markedly decreasing recovery time.

How long does dog medetomidine last?

The analgesia associated with medetomidine only lasts 15 to 30 minutes but sedation can last 1 to 2 hours. Complete recovery can take 2 to 4 hours. Within the first 3 to 5 minutes after IM injection, vomiting can occur. The effects of medetomidine can be reversed with the use of atipamezole.

Is medetomidine the same as dexmedetomidine?

Medetomidine is faster acting and more effective than dexmedetomidine following IM administration in dogs. Medetomidine may induce less vasoconstriction at injection site, faster uptake and more rapid onset of action.

Does medetomidine cause vasodilation?

Medetomidine causes peripheral vasoconstriction, which gives mucous membranes a slight mauve appearance that may be mistaken for cyanosis. The vasoconstriction is not dangerous but the poor colour of the mucous membranes could mask a true cyanosis should it occur.

How is medetomidine given?

Medetomidine (Domitor) and butorphanol can be administered together in the same syringe, by IM or IV injection. Dose rate: 10-25 mcg/kg medetomidine (0.01 – 0.025 ml/kg Domitor), depending on the degree of sedation required, plus 0.1mg/kg butorphanol (0.01ml/kg of 10mg/ml solution).

Does medetomidine cause muscle relaxation?

Alpha2-agonists such as xylazine and medetomidine are sedative-hypnotic agents that provide sedation, muscle relaxation, and analgesia.

What happens if you give ANTISEDAN IV?

Atipamezole administered IV may result in rapid relaxation of vascular tone, which coupled with bradycardia could result in cardiovascular collapse.

How does medetomidine cause sedation?

Medetomidine is a relatively new sedative analgesic drug that is approved for use in dogs in Canada. It is the most potent α2-adrenoreceptor available for clinical use in veterinary medicine and stimulates receptors centrally to produce dose-dependent sedation and analgesia.