Is CREB regulated by phosphorylation?
Is CREB regulated by phosphorylation?
The first transcription factor whose activity was shown to be regulated by phosphorylation is the cyclic AMP response element (CRE)-binding protein, CREB, and its family members the activating transcription factor 1 (ATF1) and the cAMP response element modulator (CREM).
What is the CREB pathway?
The function of CREB can be modulated via a signalling pathway resulting from the binding of serotonin and noradrenaline to post-synaptic G-protein coupled receptors. Dysfunction of these neurotransmitters is also implicated in major depressive disorder.
What activates CREB?
The BDNF activates CREB, in part, by increasing intracellular Ca2+ that leads to the activation of CaMKIV, which phosphorylates CREB. Neuronal exposure to BDNF also activates the Ras/Erk/Rsk pathway that causes CREB phosphorylation (Finkbeiner et al., 1997).
What type of gene regulation is CREB?
The CREB is one of the major regulators of neurotrophin responses since phosphorylated CREB binds to a specific sequence in the promoter of BDNF and regulates its transcription. Moreover, susceptibility genes associated with schizophrenia also target and stimulate the activity of CREB.
How is CREB phosphorylated?
CREB is phosphorylated on Ser133 by PKA (protein kinase A), promoting the recruitment of the co-activator proteins CBP (CREB-binding protein) and p300; this has been proposed to increase the transcription of CREB-dependent genes.
What is CREB and its function and how does it mediated various signals?
Abstract. CREB is a transcription factor that regulates diverse cellular responses, including proliferation, survival, and differentiation. CREB is induced by a variety of growth factors and inflammatory signals and subsequently mediates the transcription of genes containing a cAMP-responsive element.
What is the molecular function of CREB?
The CREB as a nuclear transcription factor binds to CRE (cAMP response element), regulating transcription activity of its downstream substrates, which regulate neuronal processes, including metabolism and survival and expression of different transcription factors and growth factors.
What is CREB in cell signaling?
CREB is a bZIP transcription factor that activates target genes through cAMP response elements. CREB is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses.
