How reliable is Roma score?

Data from a 472-patient study presented at the annual meeting of the Society of Gynecologic Oncologists[1] showed that ROMA used alone was highly accurate in assigning a combined pre- and postmenopausal patient population to ovarian cancer risk groups: 93.8% of EOCs were correctly classified as high likelihood.

How do you calculate Roma score?

ROMA score was calculated by the following formulas where LN is the natural logarithm.

  1. Premenopausal woman:
  2. Predictive index (PI) = − 12.0 + 2.38 * LN [HE4] + 0.0626 * LN [CA 125]
  3. Postmenopausal woman:
  4. Predictive index (PI) = − 8.09 + 1.04 * LN [HE4] + 0.732*LN [CA 125]
  5. ROMA score (%) = exp(PI)/[1 + exp(PI)] * 100.

What is Roma test for?

The ROMA value is intended to aid in assessing whether a premenopausal or postmenopausal woman who presents with an ovarian adnexal mass is at high or low likelihood of finding malignancy on surgery.

What is a Roma panel?

ROMA™ (Risk of Ovarian Malignancy Algorithm) – The risk of Ovarian Malignancy Algorithm (ROMA™) test is intended to aid in assessing the risk of ovarian cancer in women with a pelvic mass based on the patient’s HE4 and CA125 levels, and their menopausal status.

What is a normal Roma score?

In premenopausal women, a risk of ovarian malignancy algorithm (ROMA) value of 1.14 or greater indicates a high risk of finding epithelial ovarian cancer, whereas a ROMA value less than 1.14 indicates a low risk of finding epithelial ovarian cancer at surgery.

What does Roma mean in medical terms?

ROMA: Representational oligonucleotide microarray analysis. A method for the detection of genomic aberrations between any two samples of DNA. ROMA measures the relative concentration of DNA in the two samples by hybridizing differentially labeled samples to a set of probes.

What is the normal range for HE4?

Results. HE4 reference limit for healthy patients equals 85 pmol/l, which becomes 73 pmol/l and 93 pmol/l for pre and postmenopausal subgroups, respectively. There is a statistically significant correlation between HE4 serum level and smoking ( ) and there is no correlation with creatinine.

What is a high Roma score?

What is risk of ovarian malignancy algorithm?

The Risk of Ovarian Malignancy Algorithm (ROMA) is a logistic regression algorithm that utilizes the serum biomarkers HE4 and CA125 along with menopausal status to assess the risk that an ovarian cyst or pelvic mass is benign or malignant [10,11].

What is considered a high HE4 level?

If HE4 is higher than 147 pmol/l and eGFR is not below 48 ml/min/1.73m2, 95% of cases are probably malignant. In cases of those patients where the HE4 level is abnormal and eGFR is below 48 ml/min/1.73m2, CA125 concentration should be considered.

What is Roma value?

The ROMA index value is an algorithm that takes into account the levels of CA-125 and HE4 together with menopausal status using quantitative and objective parameters (18). The sensitivity and specificity of ROMA are 88.7 and 74.7%, respectively, when applied in cohorts of pre- and postmenopausal women (17).

What is Roma index?