How many MAO inhibitors are there?

All three MAOIs (isocarboxazid, phenelzine and tranylcypromine), available in the U.S. and used for the treatment of depression, are irreversible inhibitors of the enzyme monoamine oxidase. Irreversible means that the body must regenerate new monoamine oxidase enzymes to resume previous levels of enzymatic activity.

Which is the most effective MAOI?

Generally, doses of 40–60 mg/day of isocarboxazid and tranylcypromine and 60–90 mg/day of phenelzine are most effective, when tolerated. Table 1 summarizes desirable target doses of the MAOIs that are available in the United States and approved for the treatment of depression.

Is bupropion an MAOI?

Bupropion was originally classified as an “atypical” antidepressant because it does not exert the same effects as the classical antidepressants such as Monoamine Oxidase Inhibitors (MAOIs), Tricyclic Antidepressants (TCAs), or Selective Serotonin Reuptake Inhibitors (SSRIs).

Is Lexapro an MAO inhibitor?

Lexapro is not considered a monoamine oxidase inhibitor (MAOI). MAOIs work by slowing down the breakdown of serotonin and dopamine, another chemical in your brain. This also helps alleviate symptoms of depression. However, MAOIs have a higher risk of side effects and drug interactions than SSRIs such as Lexapro.

Is Cymbalta an MAOI?

Cymbalta is not a MAOI inhibitor. It is a serotonin-norepinephrine reuptake inhibitor (SNRI) type of antidepressant.

Is Nardil still available?

Kyowa Kirin has informed the Department of Health and Social Care (DHSC) that due to manufacturing challenges, Nardil has been out of stock since Summer 2019. There is no exact date of when the product will be back in stock, however the availability issues are expected to last until 2021.

Is Cymbalta a MAOI?

Is Parnate still available?

Tranylcypromine is marketed in Australia under the brand name Parnate and is used to treat symptoms of depression. Amdipharm Mercury (Australia) Pty Ltd has notified the TGA that Parnate 10 mg tablets will be in short supply from 1 November 2020 to 7 December 2020 due to manufacturing issues.

Which MAOI is best for anxiety?

Phenelzine (Nardil) has been the MAOI most researched for the treatment of panic. Another MAOI that may be effective against panic attacks is tranylcypromine (Parnate).