How does receptor density determine the sensitivity?

The greater number of cutaneous receptors in an area (receptor density), the greater the tactile sensitivity of that area. The size of an area receiving sensory information from a specific body area is directly proportional to the cutaneous receptor density.

What does receptor density mean?

The concept of receptor density is an important determinant of how various parts of the body are represented in somatosensory cortex as well as how these representations reorganize after neurological injury.

What is receptor binding potential?

In pharmacokinetics and receptor-ligand kinetics the binding potential (BP) is a combined measure of the density of “available” neuroreceptors and the affinity of a drug to that neuroreceptor.

How do you find the density of a receptor?

Therefore, the receptor density estimated in the confocal volume can be expressed as the total number of bound aptamers divided by the area covered [Eq. (5)].

How does receptor density affect sensory acuity?

Two factors determine two-point discrimination: density of sensory receptors, and size of neuronal receptive fields. The higher the number of sensory receptors in a region, the more accurate the sensory perception of the region. Fingertips have 3-4 times more density of sensory receptors than the hand.

How does receptor density and receptive field size affect your ability touch stimuli?

Large receptive fields allow the cell to detect changes over a wider area, but lead to a less-precise perception. Touch receptors are denser in glabrous skin (the type found on human fingertips and lips, for example), which is typically more sensitive and is thicker than hairy skin (4 to 5 mm versus 2 to 3 mm).

What type of somatosensory receptors are being activated in a two point discrimination task?

The tactile system, which is activated in the two-point discrimination test, employs several types of receptors. A tactile sensory receptor can be defined as the peripheral ending of a sensory neuron and its accessory structures, which may be part of the nerve cell or may come from epithelial or connective tissue.

How is binding potential measured?

The binding potential can be measured by direct modeling using plasma tracer concentration as arterial input, or as an approximate value of binding potential′ or as specific uptake ratio, when a reference region devoid of target receptor is available and a pseudo-equilibrium interval can be identified.

What is the meaning of receptor occupancy?

Receptor occupancy (RO) assays as designed to quantify and characterize the binding profile of therapeutic drugs to their targets on the cell surface. Typically, these drugs are antibody-based therapeutics that target specific receptors in order to modulate downstream signaling.

How do you calculate binding potential?

Binding potential As some receptors are occupied by endogenous ligands, the Bmax here denotes the available receptor density. Because affinity of ligand binding is the inverse of KD (radioligand equilibrium dissociation constant), the binding potential is expressed as binding potential = Bmax/KD[2].

What does a high BMAX mean?

Bmax is the maximum specific binding in the same units as Y. It is the specific binding extrapolated to very high concentrations of radioligand, and so its value is almost always higher than any specific binding measured in your experiment.