How does quinidine interact with digoxin?

On average, the serum digoxin doubles during treatment with therapeutic doses of quinidine. Almost every patient treated with quinidine will have a decrease in the renal clearance of digoxin and many will have a decrease in the volume of distribution of digoxin.

How does quinidine increase digoxin?

In addition, drug that is normally eliminated by P-gp in the bile or urine will accumulate in the body. Thus, when quinidine is coadministered with digoxin, quinidine inhibition of P-gp results in an increase in digoxin absorption and a reduction of digoxin elimination, primarily via the kidney.

Why is digoxin contraindicated with quinidine?

An interaction between quinidine and digoxin is known to occur with toxic concentrations of digoxin in the serum resulting when the two drugs are administered together. The effects can be very dangerous, especially in those patients with advanced and severe cardiac disease.

Which mechanism is responsible for interaction between quinidine and digoxin?

Considering the reduction of renal digoxin clearance, the mechanism mainly responsible for the quinidine-digoxin interaction, the decrease in renal quinidine clearance, appears to be most remarkable as well.

What interferes with digoxin absorption?

Drugs which reduce digoxin absorption include the antacids aluminium hydroxide, magnesium hydroxide and magnesium trisilicate, the antidiarrhoeals kaolin and pectin, the hypocholesterolaemic agent cholestyramine and the chemotoxins cyclophosphamide, vincristine and bleomycin.

What is quinidine used for?

Quinidine is used to treat certain types of irregular heartbeats. Quinidine is in a class of medications called antiarrhythmic medications. It works by making your heart more resistant to abnormal activity.

What drugs should not be used with digoxin?

Digoxin has many interactions, including:

  • Erythromycin and tetracycline (antibiotics)
  • Antiarrhythmic drugs (amiodarone)
  • Calcium channel blockers.
  • Over-the-counter antacids.
  • Hawthorn (an herbal remedy)
  • Black licorice.
  • Large amounts of oatmeal, milk and high-fibre cereals.

What drug Cannot be given with digoxin?

Some coadministered drugs such as macrolides and cardiovascular drugs (especially amiodarone) can cause digoxin overdose through pharmacokinetic interactions.

Is quinidine used for heart failure?

Quinidine is used for long-term treatment or prevention of heart rate problems. It’s a short-term drug treatment for malaria.

Which medication can interfere with absorption of digoxin?

Antacids may interfere with the absorption of digoxin. Kaolin-pectin may interfere with the absorption of digoxin. Metoclopramide may interfere with the absorption of digoxin. Neomycin may interfere with the absorption of digoxin.