How does isoniazid cause psychosis?

Isoniazid also inhibits the activity of brain pyridoxal-5-phosphate (produced in the body from pyridoxine), which leads to a decrease in brain gamma-aminobutyric acid and other synaptic transmitters, resulting in neurologic ill effect.

What does psychosis mean?

During a period of psychosis, a person’s thoughts and perceptions are disturbed and the individual may have difficulty understanding what is real and what is not. Symptoms of psychosis include delusions (false beliefs) and hallucinations (seeing or hearing things that others do not see or hear).

What psychiatric conditions can isoniazid cause?

Adverse effects include hepatitis, peripheral neurotoxicity, lupus like syndrome, and central nervous system effects including dysarthria, seizures, irritability and even psychosis [2]. Studies have found higher prevailing rates of mental illness, including psychosis in tuberculosis.

What are side effects of ethambutol?

Headache, loss of appetite, upset stomach, or nausea/vomiting may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Can TB cause psychosis?

The most likely TB drug involved is Cs or Trd, but psychotic symptoms may occur with FQs, H, Eto or Pto. History of psychosis is not a contra-indication to the use of the above-mentioned drugs, though psychiatric symptoms are more likely to occur in such circumstances.

What are the main side effects of ethambutol?

Headache, loss of appetite, upset stomach, or nausea/vomiting may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects.

What is ethambutol toxicity?

Ethambutol is an antimicrobial agent used frequently to treat tuberculosis. The most commonly recognized toxic effect of ethambutol is optic neuropathy, which generally is considered uncommon and reversible in medical literature.

What are the contraindications of ethambutol?

It is also contraindicated in patients with known optic neuritis unless clinical judgment determines that it may be used. ETHAMBUTOL HCl is contraindicated in patients who are unable to appreciate and report visual side effects or changes in vision (e.g., young children, unconscious patients).